Abstract
Transfusion of about 60 ml of ABO incompatible plasma in 4 units of pooled platelets precipitated severe haemolysis, unmasking the emergence of paroxysmal nocturnal haemoglobinuria (PNH), in a patient with aplastic anaemia. In vitro tests showed that her red cells were lysed by both ABO compatible and incompatible plasma from normal donors. The behaviour of this case and the in vitro results suggest that it might be hazardous to relax the longstanding recommendation on transfusing patients with PNH by restricting the washing of blood components to those containing ABO incompatible plasma.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brecher M. E., Taswell H. F. Paroxysmal nocturnal hemoglobinuria and the transfusion of washed red cells. A myth revisited. Transfusion. 1989 Oct;29(8):681–685. doi: 10.1046/j.1537-2995.1989.29890020439.x. [DOI] [PubMed] [Google Scholar]
- Najean Y., Haguenauer O. Long-term (5 to 20 years) Evolution of nongrafted aplastic anemias. The Cooperative Group for the Study of Aplastic and Refractory Anemias. Blood. 1990 Dec 1;76(11):2222–2228. [PubMed] [Google Scholar]