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ctaB, ctaA, and ctaM homologues are conserved among respiring Firmicutes and show a strong tendency to co-occur in the same genome. The phylogenic distribution of ctaM (orange, outer ring) was mapped onto the Tree of Life (29, 45). The distributions of ctaB, the gene that encodes the heme O synthase (purple, outer ring), and of ctaA, the gene that encodes the heme A synthase (teal, outer ring), are also presented.
