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. 2016 Jul 1;143(13):2376–2388. doi: 10.1242/dev.137984

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Sox2 deletion in IL after cell commitment does not affect melanotroph cell fate. Immunofluorescence for PAX7, eYFP and GR, at 18.5 dpc in Pomc-Cre mutants. PAX7 is expressed in nearly all cells of the IL in both Sox2^fl/+ and Sox2^fl/fl;Pomc-Cre;R26R^eYFP/+ embryos. GR is not present in IL in Sox2^fl/fl;Pomc-Cre;R26R^eYFP/+ embryos. There is, however, a patch of cells that are negative for PAX7 (arrow) and these ectopically express GR in mutant Sox2^fl/fl;Pomc-Cre;R26R^eYFP/+ embryos. These likely represent cells where ectopic deletion of Sox2 with the Pomc-Cre transgene occurred before endogenous Pomc expression (Fig. S4). IL is outlined.