Table 3.

Model parameters, initial values and boundaries of the Nelder–Mead algorithm

Parameter	Unit	Initial value	Upper limit	Lower limit	Fitted value AGE1.HNAAT	Fitted value CHO-K1
µ d,min	h−1	0.003	0.03	0	0.0015	0.0017
µ d,max	h−1	0.03	0.3	0	0.0123	0.0360
µ max	h−1	0.05	0.5	0	0.0161	0.0440
k Glc	mmol L−1	0.19	1.9	0	0.0605	1.8501
k Gln	mmol L−1	0.3	3	0	0.4966	3.7363
K Lys	h−1	0.005	0.05	0	0.0021	0.0010
K S,Glc	mmol L−1	0.03 (fixed)
K S,Gln	mmol L−1	0.03 (fixed)
Y Amm/Gln	–	0.4	4	0	0.8889	0.6562
Y Lac/Glc	–	1.5	15	0	0.8326	0.4707
q Glc,max	10−9 mmol cell−1 h−1	0.25	2.5	0	0.0767	0.0726
q Gln,max	10−9 mmol cell−1 h−1	0.085	0.85	0	0.0279	0.0770
q Lac,uptake,max	10−9 mmol cell−1 h−1	0.1	1	0	0.0112	0.0442