TABLE 4.

P values for association of each hormone or ratio with number of high activity allele for each SNP, by treatment group

	No. of C at rs3760091			No. of A at rs750155			No. of G at rs9282861
Hormone	oCEE	tE2	Placebo	oCEE	tE2	Placebo	oCEE	tE2	Placebo
E1	0.43	0.32	0.65	0.09	0.77	0.44	0.19	0.97	0.41
E1S	0.26	0.56	0.43	0.004	0.28	0.33	0.13	0.61	0.81
E1S/E1	0.24	0.75	0.74	0.17	0.15	0.21	0.47	0.42	0.74
E2	0.73	0.45	0.63	0.28	0.46	0.90	0.31	0.79	0.62
E2S	0.18	0.53	0.53	0.017	0.27	0.23	0.29	0.16	0.42
E2S/E2	0.044	0.54	0.21	0.33	0.44	0.06	0.86	0.97	0.54

Statistically significant associations (<0.05) are in bold. E₁, estrone; E₁S, estrone sulfate; E₂, 17β-estradiol; E₂S, estradiol sulfate; oCEE, oral conjugated equine estrogen; SNP, single nucleotide polymorphism; t, transdermal.