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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1992 Aug 1;89(15):6968–6972. doi: 10.1073/pnas.89.15.6968

Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.

M F Lyon 1, T R King 1, Y Gondo 1, J M Gardner 1, Y Nakatsu 1, E M Eicher 1, M H Brilliant 1
PMCID: PMC49626  PMID: 1495987

Abstract

Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.

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Selected References

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