Table 1.

List of cores with varying distance and angles

Compound	Structure	Distance[a,b]	Angle(θ)[b]
6		6.2 Å	73.4°
7		6.3 Å	120°
8		7.8 Å	160.9°
9		7.7 Å	115°
10		7.9 Å	115°
11		10.4 Å	139.3°
12		10.5 Å	141.6°
13		11.8 Å	168.9°
14		11.8 Å	172.1°
15		7.8 Å	79.4°
16		9.1 Å	118.8°
17		9.2 Å	108.3°
18		9.8 Å	104.3°
19		9.1 Å	124.6°
20		9.4 Å	154.5°
21		9.2 Å	168.3°
22		14.1 Å	180°
23		12.1 Å	180°
24		9.1 Å	120°
25		11.8 Å	170.7°
26		11.9 Å	166.6°
27		8.7 Å	163°
28		10.9 Å	172.2°
29		14.3 Å	160.5°

^[a]Distance measured between the oxygen bound to N-methylpiperidine and amide nitrogen of the biaryl side chain

^[b]Both distance and angles were measured in PyMOL after the 3D structures had been minimized through molecular dynamic simulations.