TABLE 2.
Ten putative PrPC ligands
| Name/Symbol | Protein region contained in the target clonea | Function |
|---|---|---|
| Vimentin (Vim) |  |
Class-III intermediate filaments found in various non-epithelial cells |
| Serine/arginine-rich protein specific kinase 2 (Srpk2) |  |
Protein involved in the phosphorylation of SR-splicing factors and the regulation of splicing. Promotes neuronal apoptosis by upregulating cyclin-D1 (CCND1) expression |
| Proprotein convertase subtilisin/kexin type 5 (Pcsk5) |  |
Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway |
| Transforming growth factor beta-1 (Tgfb1) |  |
Multifunctional protein that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it |
| Glutathione S-Transferase Mu 1 (Gstm1) |  |
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles |
| Dynein light chain Tctex type 1 D 1 (Dynlt1b) |  |
Acts as one of several noncatalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules |
| NEDD4 binding protein 1 (N4bp1) |  |
Inhibitor of the E3 ubiquitin-protein ligase ITCH |
| Catenin (cadherin-associated protein) beta 1 (Ctnnb1) |  |
Downstream component of the canonical Wnt signaling pathway. Component of an E-cadherin/catenin adhesion complex located to adherens junctions |
| Charged multivesicular body protein 2a (Chmp2a) |  |
Core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs |
| STIP1 homology and U-Box containing protein 1 (Stub1) |  |
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates toward proteasomal degradation |
a
Gray color indicates the region found in the target clone.