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. 2015 Dec 14;8(2):306–317. doi: 10.1080/19420862.2015.1116659

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — AFC mimic drug components. Drug components used in the production of a non-toxic AFC to mimic chemistry and linker species of brentuximab vedotin were based on a (A) dansyl sulfonamide ethyl amine (DSEA) moiety attached to (B) a maleimidocaproyl valine-citrulline linker species (Mal-linker-DSEA). Residual reactive mal-linker-DSEA was quenched with N-acetyl-cysteine following the conjugation step, producing a (C) quenched-linker-fluorophore (NAc-linker-DSEA) adduct species.