Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1991 Sep;44(9):753–755. doi: 10.1136/jcp.44.9.753

Immunoglobulin heavy chain patterns in reactive lymphadenopathy.

M Sundaresan 1, T Rhodes 1, A B Akosa 1
PMCID: PMC496723  PMID: 1918403

Abstract

Thirty one lymph nodes taken from 24 benign reactive cases, three cases of angiolymphoid hyperplasia with eosinophilia, one case of Kimura's disease and three cases of Hodgkin's disease, were stained for immunoglobulin heavy chains IgG, IgM, IgA and IgE using the peroxidase-antiperoxidase method. Reticular staining of germinal centres and cells containing immunoglobulin in germinal centres and extrafollicular regions were features of all groups. No staining pattern was diagnostic for any of these conditions and in particular, the reticular staining pattern of IgE in the germinal centres that is frequently reported in Kimura's disease and in angiolymphoid hyperplasia with eosinophilia was non-specific.

Full text

PDF
753

Images in this article

754Image
on p.754
754Image
on p.754

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akosa A. B., Ali M. H., Khoo C. T., Evans D. M. Angiolymphoid hyperplasia with eosinophilia associated with tetanus toxoid vaccination. Histopathology. 1990 Jun;16(6):589–593. doi: 10.1111/j.1365-2559.1990.tb01164.x. [DOI] [PubMed] [Google Scholar]
  2. Hallam L. A., Mackinlay G. A., Wright A. M. Angiolymphoid hyperplasia with eosinophilia: possible aetiological role for immunisation. J Clin Pathol. 1989 Sep;42(9):944–949. doi: 10.1136/jcp.42.9.944. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heinen E., Lilet-Leclercq C., Mason D. Y., Stein H., Boniver J., Radoux D., Kinet-Denoël C., Simar L. J. Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization. Eur J Immunol. 1984 Mar;14(3):267–273. doi: 10.1002/eji.1830140312. [DOI] [PubMed] [Google Scholar]
  4. Hui P. K., Chan J. K., Ng C. S., Kung I. T., Gwi E. Lymphadenopathy of Kimura's disease. Am J Surg Pathol. 1989 Mar;13(3):177–186. doi: 10.1097/00000478-198903000-00001. [DOI] [PubMed] [Google Scholar]
  5. Jones D. B., Castleden M., Smith J. L., Mepham B. L., Wright D. H. Immunopathology of angioimmunoblastic lymphadenopathy. Br J Cancer. 1978 Jun;37(6):1053–1062. doi: 10.1038/bjc.1978.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kuo T. T., Shih L. Y., Chan H. L. Kimura's disease. Involvement of regional lymph nodes and distinction from angiolymphoid hyperplasia with eosinophilia. Am J Surg Pathol. 1988 Nov;12(11):843–854. [PubMed] [Google Scholar]
  7. Maeda K., Jimbow K. Kimura's disease: immunohistochemistry of infiltrating cells using monoclonal and polyclonal antibodies. J Dermatol. 1986 Jun;13(3):190–195. doi: 10.1111/j.1346-8138.1986.tb02925.x. [DOI] [PubMed] [Google Scholar]
  8. Moesner J., Pallesen R., Sørensen B. Angiolymphoid hyperplasia with eosinophilia (Kimura's disease). A case with dermal lesions in the knee region and a popliteal arteriovenous fistula. Arch Dermatol. 1981 Oct;117(10):650–653. doi: 10.1001/archderm.117.10.650. [DOI] [PubMed] [Google Scholar]
  9. Norton A. J., Isaacson P. G. Detailed phenotypic analysis of B-cell lymphoma using a panel of antibodies reactive in routinely fixed wax-embedded tissue. Am J Pathol. 1987 Aug;128(2):225–240. [PMC free article] [PubMed] [Google Scholar]
  10. Peters J. P., Rademakers L. H., Roelofs J. M., de Jong D., van Unnik J. A. Distribution of dendritic reticulum cells in follicular lymphoma and reactive hyperplasia. Light microscopic identification and general morphology. Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;46(3):215–228. doi: 10.1007/BF02890311. [DOI] [PubMed] [Google Scholar]
  11. Stein H., Gerdes J., Mason D. Y. The normal and malignant germinal centre. Clin Haematol. 1982 Oct;11(3):531–559. [PubMed] [Google Scholar]
  12. Tada T., Ishizaka K. Distribution of gamma E-forming cells in lymphoid tissues of the human and monkey. J Immunol. 1970 Feb;104(2):377–387. [PubMed] [Google Scholar]
  13. Takenaka T., Okuda M., Usami A., Kawabori S., Ogami Y. Histological and immunological studies on eosinophilic granuloma of soft tissue, so-called Kimura's disease. Clin Allergy. 1976 Jan;6(1):27–39. doi: 10.1111/j.1365-2222.1976.tb01409.x. [DOI] [PubMed] [Google Scholar]
  14. Wright D. H., Padley N. R., Judd M. A. Angiolymphoid hyperplasia with eosinophilia simulating lymphadenopathy. Histopathology. 1981 Mar;5(2):127–140. doi: 10.1111/j.1365-2559.1981.tb01773.x. [DOI] [PubMed] [Google Scholar]
  15. van der Valk P., van der Loo E. M., Jansen J., Daha M. R., Meijer C. J. Analysis of lymphoid and dendritic cells in human lymph node, tonsil and spleen. A study using monoclonal and heterologous antibodies. Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;45(2):169–185. doi: 10.1007/BF02889863. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES