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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1991 Jul;44(7):573–575. doi: 10.1136/jcp.44.7.573

Prealbumin in the diagnosis of bronchopulmonary carcinoid tumours.

U R Suresh 1, S Wilkes 1, P S Hasleton 1
PMCID: PMC496797  PMID: 1713221

Abstract

The reliability of prealbumin as a diagnostic marker was studied in 60 cases of bronchopulmonary carcinoid tumours. There were differences in the incidence of positivity between typical and atypical carcinoids (well differentiated neuroendocrine carcinomas). Seventy five per cent of the carcinoid tumours were positive for prealbumin; (86.7% typical and 63.3% atypical carcinoids). In 15 cases, which were Grimelius negative, 10 were prealbumin positive. Only 8.3% carcinoids were negative with both prealbumin and Grimelius stains. Ten squamous, 10 adeno- and 10 small cell carcinomas showed only occasional scattered prealbumin positive cells. It is concluded that prealbumin is a useful marker for bronchopulmonary carcinoid tumours. It is cheap, readily available, and should be considered part of routine diagnostic procedures for the diagnosis of carcinoid tumours.

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Selected References

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  1. Bergh J., Esscher T., Steinholtz L., Nilsson K., Påhlman S. Immunocytochemical demonstration of neuron-specific enolase (NSE) in human lung cancers. Am J Clin Pathol. 1985 Jul;84(1):1–7. doi: 10.1093/ajcp/84.1.1. [DOI] [PubMed] [Google Scholar]
  2. Blondal T., Grimelius L., Nou E., Wilander E., Aberg T. Argyrophil carcinoid tumors of the lung. Incidence, clinical study, and follow-up of 46 patients. Chest. 1980 Dec;78(6):840–844. doi: 10.1378/chest.78.6.840. [DOI] [PubMed] [Google Scholar]
  3. Bussolati G., Papotti M., Sapino A. Binding of antibodies against human prealbumin to intestinal and bronchial carcinoids and to pancreatic endocrine tumours. Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;45(1):15–22. doi: 10.1007/BF02889848. [DOI] [PubMed] [Google Scholar]
  4. Grote T. H., Macon W. R., Davis B., Greco F. A., Johnson D. H. Atypical carcinoid of the lung. A distinct clinicopathologic entity. Chest. 1988 Feb;93(2):370–375. doi: 10.1378/chest.93.2.370. [DOI] [PubMed] [Google Scholar]
  5. Hasleton P. S., Gomm S., Blair V., Thatcher N. Pulmonary carcinoid tumours: a clinico-pathological study of 35 cases. Br J Cancer. 1986 Dec;54(6):963–967. doi: 10.1038/bjc.1986.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Linnoila R. I., Mulshine J. L., Steinberg S. M., Funa K., Matthews M. J., Cotelingam J. D., Gazdar A. F. Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas. Am J Clin Pathol. 1988 Dec;90(6):641–652. doi: 10.1093/ajcp/90.6.641. [DOI] [PubMed] [Google Scholar]
  7. Miller I. D., Reid W. A., Liddle C. N., Horne C. H. Immunolocalization of prealbumin as a marker for carcinoid tumours. J Pathol. 1984 Jul;143(3):199–204. doi: 10.1002/path.1711430308. [DOI] [PubMed] [Google Scholar]
  8. Walts A. E., Said J. W., Shintaku I. P., Lloyd R. V. Chromogranin as a marker of neuroendocrine cells in cytologic material--an immunocytochemical study. Am J Clin Pathol. 1985 Sep;84(3):273–277. doi: 10.1093/ajcp/84.3.273. [DOI] [PubMed] [Google Scholar]
  9. al-Saffar N., White A., Moore M., Hasleton P. S. Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours. Br J Cancer. 1988 Dec;58(6):762–766. doi: 10.1038/bjc.1988.304. [DOI] [PMC free article] [PubMed] [Google Scholar]

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