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. 1991 Jul;44(7):596–599. doi: 10.1136/jcp.44.7.596

Serum C-reactive protein and neopterin concentrations in patients with viral or bacterial infection.

A C Shaw 1
PMCID: PMC496802  PMID: 1856293

Abstract

Serum C-reactive protein and neopterin concentrations were measured in samples taken at an early stage in different types of infection to see whether the combination of markers could contribute to the diagnosis of infection and help distinguish between bacterial and viral infections, tuberculosis, and infections due to "other" pathogens. Both markers were significantly raised in all categories of infection compared with controls, and there were significant differences between the means of both markers when comparing several of the categories of infection. Only C-reactive protein concentrations in bacteraemic patients, however, were both sensitive and specific at distinguishing the type of infection. The additional use of neopterin estimation played only a minor part in increasing the specificity of diagnosis in tuberculosis and in viral infections. On the basis of this study it was not considered worth the time and expense of performing neopterin assays in addition to C-reactive protein estimations to differentiate viral from bacterial infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fuchs D., Hausen A., Kofler M., Kosanowski H., Reibnegger G., Wachter H. Neopterin as an index of immune response in patients with tuberculosis. Lung. 1984;162(6):337–346. doi: 10.1007/BF02715666. [DOI] [PubMed] [Google Scholar]
  2. Fuchs D., Hausen A., Reibnegger G., Werner E. R., Dierich M. P., Wachter H. Neopterin as a marker for activated cell-mediated immunity: application in HIV infection. Immunol Today. 1988 May;9(5):150–155. doi: 10.1016/0167-5699(88)91203-0. [DOI] [PubMed] [Google Scholar]
  3. Gill C. W., Bush W. S., Burleigh W. M., FIscher C. L. An evaluation of a C-reactive protein assay using a rate immunonephelometric procedure. Am J Clin Pathol. 1981 Jan;75(1):50–55. doi: 10.1093/ajcp/75.1.50. [DOI] [PubMed] [Google Scholar]
  4. Hurlimann J., Thorbecke G. J., Hochwald G. M. The liver as the site of C-reactive protein formation. J Exp Med. 1966 Feb 1;123(2):365–378. doi: 10.1084/jem.123.2.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kushner I., Feldmann G. Control of the acute phase response. Demonstration of C-reactive protein synthesis and secretion by hepatocytes during acute inflammation in the rabbit. J Exp Med. 1978 Aug 1;148(2):466–477. doi: 10.1084/jem.148.2.466. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lindbäck S., Hellgren U., Julander I., Hansson L. O. The value of C-reactive protein as a marker of bacterial infection in patients with septicaemia/endocarditis and influenza. Scand J Infect Dis. 1989;21(5):543–549. doi: 10.3109/00365548909037883. [DOI] [PubMed] [Google Scholar]
  7. Maasilta P., Kostiala A. A. Serum levels of C-reactive protein in patients with pulmonary tuberculosis and malignant tumors of the chest. Infection. 1989 Jan-Feb;17(1):13–14. doi: 10.1007/BF01643491. [DOI] [PubMed] [Google Scholar]
  8. Mackie P. H., Crockson R. A., Stuart J. C-reactive protein for rapid diagnosis of infection in leukaemia. J Clin Pathol. 1979 Dec;32(12):1253–1256. doi: 10.1136/jcp.32.12.1253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McCabe R. E., Remington J. S. C-reactive protein in patients with bacteremia. J Clin Microbiol. 1984 Sep;20(3):317–319. doi: 10.1128/jcm.20.3.317-319.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McCarthy P. L., Frank A. L., Ablow R. C., Masters S. J., Dolan T. F., Jr Value of the C-reactive protein test in the differentiation of bacterial and viral pneumonia. J Pediatr. 1978 Mar;92(3):454–456. doi: 10.1016/s0022-3476(78)80448-x. [DOI] [PubMed] [Google Scholar]
  11. McConkey B., Crockson R. A., Crockson A. P. The assessment of rheumatoid arthritis. A study based on measurements of the serum acute-phase reactants. Q J Med. 1972 Apr;41(162):115–125. [PubMed] [Google Scholar]
  12. McCord F. B., Jenkins J. G., Lim J. H. C reactive protein concentration as screening test for bacterial infection in febrile children. Br Med J (Clin Res Ed) 1985 Dec 14;291(6510):1685–1686. doi: 10.1136/bmj.291.6510.1685-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Myara I., Atger V., Cosson C., Guillemain R., Amrein C., Dreyfus G., Moatti N. Simultaneous determination of serum neopterin and C-reactive protein as markers of infection in heart-transplant recipients. Clin Chem. 1989 Jun;35(6):1258–1259. [PubMed] [Google Scholar]
  14. Peltola H., Holmberg C. Rapidity of C-reactive protein in detecting potential septicemia. Pediatr Infect Dis. 1983 Sep-Oct;2(5):374–376. doi: 10.1097/00006454-198309000-00009. [DOI] [PubMed] [Google Scholar]
  15. Peltola H., Saarinen U. M., Siimes M. A. C-reactive protein in rapid diagnosis and follow-up of bacterial septicemia in children with leukemia. Pediatr Infect Dis. 1983 Sep-Oct;2(5):370–373. doi: 10.1097/00006454-198309000-00008. [DOI] [PubMed] [Google Scholar]
  16. Pepys M. B. C-reactive protein fifty years on. Lancet. 1981 Mar 21;1(8221):653–657. doi: 10.1016/s0140-6736(81)91565-8. [DOI] [PubMed] [Google Scholar]
  17. Rose P. E., Johnsdon S. A., Meakin M., Mackie P. H., Stuart J. Serial study of C-reactive protein during infection in leukaemia. J Clin Pathol. 1981 Mar;34(3):263–266. doi: 10.1136/jcp.34.3.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Schofield K. P., Voulgari F., Gozzard D. I., Leyland M. J., Beeching N. J., Stuart J. C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia. J Clin Pathol. 1982 Aug;35(8):866–869. doi: 10.1136/jcp.35.8.866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Strohmaier W., Redl H., Schlag G., Inthorn D. D-erythro-neopterin plasma levels in intensive care patients with and without septic complications. Crit Care Med. 1987 Aug;15(8):757–760. doi: 10.1097/00003246-198708000-00009. [DOI] [PubMed] [Google Scholar]
  20. Wachter H., Hausen A., Grassmayr K. Erhöhte Ausscheidung von Neopterin im Harn von Patienten mit malignen Tumoren und mit Viruserkrankungen. Hoppe Seylers Z Physiol Chem. 1979 Dec;360(12):1957–1960. [PubMed] [Google Scholar]

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