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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Psychoneuroendocrinology. 2015 Dec 23;65:109–117. doi: 10.1016/j.psyneuen.2015.12.004

Figure 3. Chronic stress in adolescence leads to an increase PVN CRH mRNA expression in adolescent rats and a decrease in GR mRNA expression in the PVN seen in adulthood.

Figure 3

A) Representative image of CRH mRNA in-situ radiograph at the level of −2.12 mm (bregma). Scale bar=500µm. B) Adolescent rats exposed to CVS showed an increase in CRH mRNA expression in the PVN when compared to non-stress age-matched controls. C) Representative image of GR mRNA in-situ radiograph at the level of −2.12 mm (bregma). Scale bar=500µm. D) Prior exposure to CVS led to a down regulation of GR mRNA expression in the adult rats when compared to non-stress age-matched controls. # p<0.05 significant effect of stress within age group, ^p<0.05 significant effect of age within stress group. Data presented as mean ± SEM, n=10–12.