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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1992 Aug 1;89(15):7252–7256. doi: 10.1073/pnas.89.15.7252

Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system.

B Dietzschold 1, M Kao 1, Y M Zheng 1, Z Y Chen 1, G Maul 1, Z F Fu 1, C E Rupprecht 1, H Koprowski 1
PMCID: PMC49684  PMID: 1496020

Abstract

The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was related to the mAb's ability to inhibit virus spread from cell to cell and to restrict rabies virus RNA transcription. Since treatment of rabies virus-infected cells with virus-neutralizing mAbs results in an endocytosis of the antibody, we hypothesize that an antibody may exert its inhibitory activity even after uptake by the cell. Post-exposure treatment of rats with a mAb that inhibited both virus spread and virus RNA transcription in vitro resulted in viral clearance from the central nervous system and protected the animals against a lethal rabies virus infection.

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Selected References

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