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. 1991 May;44(5):416–418. doi: 10.1136/jcp.44.5.416

Prognostic value of proliferative activity in lymph node metastases of patients with breast cancer.

P J van Diest 1, E Matze-Cok 1, J P Baak 1
PMCID: PMC496875  PMID: 2045501

Abstract

Whether the proliferative activity of distant metastases could be predicted by the proliferation in axillary lymph node metastases was investigated in 304 lymph nodes metastases of 52 patients with breast cancer who had not received adjuvant treatment. The standard deviation of the mean mitotic index (MI)--the average number of mitoses per field in 10 high power fields--was of the best prognostic valve in univariate survival analysis. None of the classic (volume % epithelium and stroma) or morphometric features (nuclear area, nuclear axis ratio. shape factors) provided significant results. In Cox regression analysis a multivariate combination of the mean MI, the SD of the mean MI, and the maximum MI emerged, which provided a satisfying means of differentiating patients with a good (68% survival) and a poor (28% survival) prognosis. Proliferation variables derived from axillary lymph node metastases of patients with breast cancer can predict the clinical course of distant metastases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baak J. P. Mitosis counting in tumors. Hum Pathol. 1990 Jul;21(7):683–685. doi: 10.1016/0046-8177(90)90026-2. [DOI] [PubMed] [Google Scholar]
  2. Baak J. P., Van Dop H., Kurver P. H., Hermans J. The value of morphometry to classic prognosticators in breast cancer. Cancer. 1985 Jul 15;56(2):374–382. doi: 10.1002/1097-0142(19850715)56:2<374::aid-cncr2820560229>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  3. Fleege J. C., van Diest P. J., Baak J. P. Computer assisted efficiency testing of different sampling methods for selective nuclear graphic tablet morphometry. Lab Invest. 1990 Aug;63(2):270–275. [PubMed] [Google Scholar]
  4. Maehle B. O., Skjaerven R. A prognostic index based on the mean nuclear area of breast cancer cells and efferent vascular invasion in the axillary nodes. Diagn Histopathol. 1983 Jul-Dec;6(3-4):221–228. [PubMed] [Google Scholar]
  5. Maehle B. O., Skjaerven R., Hartveit F. Efferent vascular invasion and the mean nuclear area of axillary nodal tumour cells in breast cancer. Diagn Histopathol. 1982 Oct-Dec;5(4):297–300. [PubMed] [Google Scholar]
  6. Maehle B. O., Thoresen S., Skjaerven R., Hartveit F. Mean nuclear area and histological grade of axillary-node tumour in breast cancer, related to prognosis. Br J Cancer. 1982 Jul;46(1):95–100. doi: 10.1038/bjc.1982.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Nemoto T., Vana J., Bedwani R. N., Baker H. W., McGregor F. H., Murphy G. P. Management and survival of female breast cancer: results of a national survey by the American College of Surgeons. Cancer. 1980 Jun 15;45(12):2917–2924. doi: 10.1002/1097-0142(19800615)45:12<2917::aid-cncr2820451203>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  8. Tosi P., Luzi P., Sforza V., Santopietro R., Bindi M., Tucci E., Barbini P., Baak J. P. Correlation between morphometrical parameters and disease-free survival in ductal breast cancer treated only by surgery. Appl Pathol. 1986;4(1-2):33–42. [PubMed] [Google Scholar]
  9. Uyterlinde A. M., Schipper N. W., Baak J. P. Comparison of extent of disease and morphometric and DNA flow cytometric prognostic factors in invasive ductal breast cancer. J Clin Pathol. 1987 Dec;40(12):1432–1436. doi: 10.1136/jcp.40.12.1432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Uyterlinde A. M., Schipper N. W., Baak J. P., Peterse H., Matze E. Limited prognostic value of cellular DNA content to classical and morphometrical parameters in invasive ductal breast cancer. Am J Clin Pathol. 1988 Mar;89(3):301–307. doi: 10.1093/ajcp/89.3.301. [DOI] [PubMed] [Google Scholar]
  11. van der Linden H. C., Baak J. P., Lindeman J., Hermans J., Meyer C. J. Morphometry and breast cancer. II. Characterisation of breast cancer cells with high malignant potential in patients with spread to lymph nodes: preliminary results. J Clin Pathol. 1986 Jun;39(6):603–609. doi: 10.1136/jcp.39.6.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. van der Linden J. C., Baak J. P., Lindeman J., Hermans J., Meyer C. J. Prospective evaluation of prognostic value of morphometry in patients with primary breast cancer. J Clin Pathol. 1987 Mar;40(3):302–306. doi: 10.1136/jcp.40.3.302. [DOI] [PMC free article] [PubMed] [Google Scholar]

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