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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Bioessays. 2016 Mar 15;38(5):410–419. doi: 10.1002/bies.201500171

Figure 3.

Figure 3

H3.3 transcripts and protein levels in the soluble nuclear pool are induced by a variety of neuronal stimuli: neurotrophin signaling (e.g. brain-derived growth factor, BDNF), glutamate receptor activation, and membrane depolarization. Sufficient soluble H3.3 levels are required for nucleosomal turnover and activity-dependent neuronal transcription.