This study provides data that reveal a significant increased risk of breakthrough febrile UTI in patients with onset of VUR at 35% or less estimated bladder capacity. As the authors note, this is an easily reportable variable at VCUG that can provide additional information for clinical decision making. The future of VUR treatment rests on our ability to determine which patients will suffer the consequences of VUR. This study provides us with an important piece to the VUR puzzle. We must continue to direct our research efforts toward determining who with VUR is at increased risk for febrile UTIs and their long-term effects.
