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. 1991 Feb;44(2):126–129. doi: 10.1136/jcp.44.2.126

Increased central immunoreactive beta-endorphin content in patients with Wernicke-Korsakoff syndrome and in alcoholics.

J A Summers 1, P T Pullan 1, J J Kril 1, C G Harper 1
PMCID: PMC496973  PMID: 1650797

Abstract

beta-endorphin, adrenocorticotrophin, and alpha-melanocyte stimulating hormone were measured by radioimmunoassay in three areas of human brain at necropsy in seven subjects with Wernicke-Korsakoff syndrome and in 52 controls. Thiamin concentration in six brain areas was also measured. Mamillary body beta-endorphin concentrations were significantly increased in those with the syndrome compared with controls, and those controls with high alcohol intake showed increased mamillary body beta-endorphin compared with controls with low alcohol intake. Brain thiamin concentration was similar in both groups, with the exception of the brainstem, where it was reduced in subjects with Wernicke-Korsakoff syndrome. Thalamic beta-endorphin in controls was inversely correlated with thiamin in frontal white matter, frontal cortex, parietal white matter and parietal cortex, while beta-endorphin in the hypothalamus of patients was inversely correlated with thiamin in frontal cortex, parietal white matter, thalamus and brainstem. These results suggest that there is a disturbance of the endorphinergic system in Wernicke-Korsakoff syndrome which may be related to alcohol intake.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abuzzahab F. S., Sr, Will J. C., Zimmermann R. L. Effects of single dose ACTH 4-10 versus placebo on the memory of symptomatic geriatric volunteers. J Clin Psychopharmacol. 1982 Feb;2(1):65–69. doi: 10.1097/00004714-198202000-00011. [DOI] [PubMed] [Google Scholar]
  2. Born J., Fehm H. L., Voigt K. H. ACTH and attention in humans: a review. Neuropsychobiology. 1986;15(3-4):165–186. doi: 10.1159/000118261. [DOI] [PubMed] [Google Scholar]
  3. Bostock E., Gallagher M., King R. A. Effects of opioid microinjections into the medial septal area on spatial memory in rats. Behav Neurosci. 1988 Oct;102(5):643–652. doi: 10.1037//0735-7044.102.5.643. [DOI] [PubMed] [Google Scholar]
  4. Branconnier R. J., Cole J. O., Gardos G. ACTH 4-10 in the amelioration of neuropsychological symptomatology associated with senile organic brain syndrome. Psychopharmacology (Berl) 1979 Mar 22;61(2):161–165. doi: 10.1007/BF00426731. [DOI] [PubMed] [Google Scholar]
  5. Cuello A. C. Central distribution of opioid peptides. Br Med Bull. 1983 Jan;39(1):11–16. doi: 10.1093/oxfordjournals.bmb.a071784. [DOI] [PubMed] [Google Scholar]
  6. Drago F., Continella G., Scapagnini U. Behavioral activity of a short chain ACTH analog. Pharmacol Biochem Behav. 1984 May;20(5):689–695. doi: 10.1016/0091-3057(84)90186-2. [DOI] [PubMed] [Google Scholar]
  7. FANG S. C., BUTTS J. S. Microbiological assay method for thiamine using Lactobacillus fermenti 36 as test organism. Proc Soc Exp Biol Med. 1951 Nov;78(2):463–466. doi: 10.3181/00379727-78-19104. [DOI] [PubMed] [Google Scholar]
  8. Genazzani A. R., Nappi G., Facchinetti F., Mazzella G. L., Parrini D., Sinforiani E., Petraglia F., Savoldi F. Central deficiency of beta-endorphin in alcohol addicts. J Clin Endocrinol Metab. 1982 Sep;55(3):583–586. doi: 10.1210/jcem-55-3-583. [DOI] [PubMed] [Google Scholar]
  9. Gianoulakis C., Barcomb A. Effect of acute ethanol in vivo and in vitro on the beta-endorphin system in the rat. Life Sci. 1987 Jan 5;40(1):19–28. doi: 10.1016/0024-3205(87)90247-5. [DOI] [PubMed] [Google Scholar]
  10. Gianoulakis C., Chan J. S., Kalant H., Chrétien M. Chronic ethanol treatment alters the biosynthesis of beta-endorphin by the rat neurointermediate lobe. Can J Physiol Pharmacol. 1983 Sep;61(9):967–976. doi: 10.1139/y83-145. [DOI] [PubMed] [Google Scholar]
  11. Harper C. Wernicke's encephalopathy: a more common disease than realised. A neuropathological study of 51 cases. J Neurol Neurosurg Psychiatry. 1979 Mar;42(3):226–231. doi: 10.1136/jnnp.42.3.226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Iacono R. P., Sandyk R. Thiamine deficiency and the intrinsic opioids in the Wernicke-Korsakoff syndrome. J Cereb Blood Flow Metab. 1986 Oct;6(5):630–631. doi: 10.1038/jcbfm.1986.111. [DOI] [PubMed] [Google Scholar]
  13. Iacono R., Sandyk R. Wernicke-Korsakoff encephalopathy and the endorphin system. Postgrad Med J. 1986 Apr;62(726):315–315. doi: 10.1136/pgmj.62.726.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Izquierdo I., Dias R. D. Effect of ACTH, epinephrine, beta-endorphin, naloxone, and of the combination of naloxone or beta-endorphin with ACTH or epinephrine on memory consolidation. Psychoneuroendocrinology. 1983;8(1):81–87. doi: 10.1016/0306-4530(83)90043-4. [DOI] [PubMed] [Google Scholar]
  15. Jeffcoate W. J., Rees L. H., Lowry P. J., Besser G. M. A specific radioimmunoassay for human beta-lipotropin. J Clin Endocrinol Metab. 1978 Jul;47(1):160–167. doi: 10.1210/jcem-47-1-160. [DOI] [PubMed] [Google Scholar]
  16. Krieger D. T., Liotta A., Brownstein M. J. Presence of corticotropin in brain of normal and hypophysectomized rats. Proc Natl Acad Sci U S A. 1977 Feb;74(2):648–652. doi: 10.1073/pnas.74.2.648. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Miller L. H., Groves G. A., Bopp M. J., Kastin A. J. A neuroheptapeptide influence on cognitive functioning in the elderly. Peptides. 1980 Spring;1(1):55–57. doi: 10.1016/0196-9781(80)90036-4. [DOI] [PubMed] [Google Scholar]
  18. Morley J. E. Neuropeptides, behavior, and aging. J Am Geriatr Soc. 1986 Jan;34(1):52–62. doi: 10.1111/j.1532-5415.1986.tb06340.x. [DOI] [PubMed] [Google Scholar]
  19. Patterson T. A., Schulteis G., Alvarado M. C., Martinez J. L., Jr, Bennett E. L., Rosenzweig M. R., Hruby V. J. Influence of opioid peptides on learning and memory processes in the chick. Behav Neurosci. 1989 Apr;103(2):429–437. doi: 10.1037//0735-7044.103.2.429. [DOI] [PubMed] [Google Scholar]
  20. Rees L. H., Cook D. M., Kendall J. W., Allen C. F., Kramer R. M., Ratcliffe J. G., Knight R. A. A radioimmunoassay for rat plasma ACTH. Endocrinology. 1971 Jul;89(1):254–261. doi: 10.1210/endo-89-1-254. [DOI] [PubMed] [Google Scholar]
  21. Ruffing D. M., Domino E. F. First dose behavioral tolerance to phencyclidine on food-rewarded bar pressing behavior in the rat. Psychopharmacology (Berl) 1980;69(1):1–4. doi: 10.1007/BF00426513. [DOI] [PubMed] [Google Scholar]
  22. Sandi C., Borrell J., Guaza C. Beta-endorphin administration interferes with the acquisition and initial maintenance of ethanol preference in the rat. Physiol Behav. 1989 Jan;45(1):87–92. doi: 10.1016/0031-9384(89)90169-8. [DOI] [PubMed] [Google Scholar]
  23. Sandman C. A., George J. M., Nolan J. D., van Riezen H., Kastin A. J. Enhancement of attention in man with ACTH/MSH 4-10. Physiol Behav. 1975 Oct;15(5):427–431. doi: 10.1016/0031-9384(75)90209-7. [DOI] [PubMed] [Google Scholar]
  24. Sandman C. A., George J., McCanne T. R., Nolan J. D., Kaswan J., Kastin A. J. MSH/ACTH 4-10 influences behavioral and physiological measures of attention. J Clin Endocrinol Metab. 1977 May;44(5):884–891. doi: 10.1210/jcem-44-5-884. [DOI] [PubMed] [Google Scholar]
  25. Sandman C. A., Kastin A. J. The influence of fragments of the LPH chains on learning, memory and attention in animals and man. Pharmacol Ther. 1981;13(1):39–60. doi: 10.1016/0163-7258(81)90066-8. [DOI] [PubMed] [Google Scholar]
  26. Sandyk R., Iacono R. P. Is excessive opioid activity relevant to the Korsakoff psychosis? Int J Neurosci. 1986 Nov;30(4):311–315. doi: 10.3109/00207458608985683. [DOI] [PubMed] [Google Scholar]
  27. Savoldi F., Mazzella G. L., Facchinetti F., Nappi G., Petraglia F., Sinforiani E., Parrini D., Genazzani A. R. Beta-endorphin, beta-lipotropin and adrenocorticotropic hormone levels in cerebrospinal fluid, and brain damage in chronic alcoholics. Eur Neurol. 1983;22(4):265–271. doi: 10.1159/000115570. [DOI] [PubMed] [Google Scholar]
  28. Seizinger B. R., Bovermann K., Höllt V., Herz A. Enhanced activity of the beta-endorphinergic system in the anterior and neurointermediate lobe of the rat pituitary after chronic treatment with ethanol liquid diet. J Pharmacol Exp Ther. 1984 Aug;230(2):455–461. [PubMed] [Google Scholar]
  29. Summers J. A., Pullan P. T., Curnow D. H. Effect of thiamin deficiency on adrenocorticotrophin and vasopressin in the rat hypothalamus. Horm Metab Res. 1986 Apr;18(4):280–280. doi: 10.1055/s-2007-1012295. [DOI] [PubMed] [Google Scholar]
  30. Vendite D., Rocha J. B., Mello C. F., Souza D. O. Effects of undernutrition during suckling and of post-training beta-endorphin administration on avoidance performances of adult rats. Braz J Med Biol Res. 1987;20(6):731–740. [PubMed] [Google Scholar]
  31. Zager E. L., Black P. M. Neuropeptides in human memory and learning processes. Neurosurgery. 1985 Aug;17(2):355–369. doi: 10.1227/00006123-198508000-00023. [DOI] [PubMed] [Google Scholar]

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