Erratum to: The neurological and ophthalmological manifestations of SPG4-related hereditary spastic paraplegia

Erratum to: J Neurol (2013) 260:906–909 DOI 10.1007/s00415-012-6780-3

There is unfortunately a mistake in the protein notation for one of the SPG4 mutations in Table 1. The c.1253_1255delAAG mutation was identified in Patient 5. The amino acid change resulting from this deletion is p.Glu418del, not p.E418fsX198.

Table 1.

Molecular genetic and ophthalmological features of the SPG4 patient cohort

Patient	Sex	Age (years)	SPG4 mutation		BCVA RE-LE	Optic discs/OCT measurements	Eye movements	Visual electrophysiology
			Exon	cDNA change/consequence
1	F	31	5	c.743C>G/p.S245X	20/20-20/20	Normal/no RNFL thinning	Normal	Normal
2	M	53	5	c.743C>G/p.S245X	20/20-20/20	Normal/no RNFL thinning	Horizontal SWJ/saccadic pursuit	Normal
3	F	50	6	c.937delG/p.D313fsX1	20/20-20/20	Normal/no RNFL thinning	Normal	Normal
4	F	55	4–17	del exon 4-17/large-scale deletion	20/20-20/20	Normal/no RNFL thinning	Normal	Normal
5	F	29	10	c.1253_1255delAAG/p.Glu418del	20/20-20/20	Normal/no RNFL thinning	Horizontal SWJ/saccadic pursuit	Normal
6	F	25	11	c.1442_1443insA/p.V482fsX5	20/20-20/20	Normal/no RNFL thinning	Normal	Normal
7	F	55	11	c.1442_1443insA/p.V482fsX5	20/20-20/20	Normal/no RNFL thinning	Horizontal SWJ/saccadic pursuit	Normal
8	F	49	11	c.1414G>A/p.V472I	20/20-20/20	Normal/no RNFL thinning	Normal	Normal
9	F	72	11	c.1384A>G/p.K462E	20/60-20/30	Normal/no RNFL thinning	Normal	Normal
10	M	65	11	c.1081C>A; c.1082T>A/p.L361N	20/20-20/20	Normal/no RNFL thinning	Normal	Normal

BCVA best-corrected visual acuities, cDNA complementary DNA, LE left eye, OCT optical coherence tomography, RE right eye, RNFL retinal nerve fibre layer, SWJ square wave jerks

The correct table is given in the following page.