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. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: Leukemia. 2016 Apr 5;30(8):1682–1690. doi: 10.1038/leu.2016.70

Fig. 6. E2F7 and BIM are BMI1 targets in Ph+ ALL primary cells and E2F7/BIM silencing rescues, in part, the leukemogenesis of BMI1-silenced BV173 cells in NSG mice.

Fig. 6

(A) Western blot shows the increased expression of BIM and E2F7 in Ph+ ALL#1222 patient derived primary cells. βACTIN is shown as loading control.

(B) Kaplan-Meier plot shows survival of NSG mice injected with 2×106 untreated or Doxy-treated BIM/E2F7-silenced shBMI1-BV173 cells. In the Doxy-treated group, mice were continuously treated with Doxy in the drinking water (2 g/L) starting three days post-cell injection. Survival curves of Doxy treated mice injected with shBMI1-BV173 cells are shown as control. Statistical analysis: log rank test..