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. 1982 Jan;35(1):1–13. doi: 10.1136/jcp.35.1.1

Cervical intraepithelial neoplasia.

C H Buckley, E B Butler, H Fox
PMCID: PMC497441  PMID: 7037858

Abstract

The theoretical and practical reasons for replacing the terms "cervical dysplasia" and "cervical carcinoma in situ" by the single diagnostic entity of "cervical intraepithelial neoplasia" are reviewed and the advantages and drawbacks of this newer terminology discussed. The histological characteristics and cytological features of the various grades of cervical intraepithelial neoplasia are described and the differential diagnosis of this lesion is considered.

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Selected References

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  1. Briggs R. M. Dysplasia and early neoplasia of the uterine cervix. A review. Obstet Gynecol Surv. 1979 Jan;34(1):70–99. [PubMed] [Google Scholar]
  2. Burghardt E. Premalignant conditions of the cervix. Clin Obstet Gynaecol. 1976 Aug;3(2):257–294. [PubMed] [Google Scholar]
  3. Cocker J., Fox H., Langley F. A. Consistency in the histological diagnosis of epithelial abnormalities of the cervix uteri. J Clin Pathol. 1968 Jan;21(1):67–70. doi: 10.1136/jcp.21.1.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fidler H. K., Boyes D. A., Worth A. J. Cervical cancer detection in British Columbia. A progress report. J Obstet Gynaecol Br Commonw. 1968 Apr;75(4):392–404. doi: 10.1111/j.1471-0528.1968.tb00136.x. [DOI] [PubMed] [Google Scholar]
  5. Govan A. D., Haines R. M., Langley F. A., Taylor C. W., Woodcock A. S. The histology and cytology of changes in the epithelium of the cervix uteri. J Clin Pathol. 1969 Jul;22(4):383–395. doi: 10.1136/jcp.22.4.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gupta P. K., Burroughs F., Luff R. D., Frost J. K., Erozan Y. S. Epithelial atypias associated with intrauterine contraceptive devices (IUD). Acta Cytol. 1978 Sep-Oct;22(5):286–291. [PubMed] [Google Scholar]
  7. Husain O. A., Butler E. B., Evans D. M., Macgregor J. E., Yule R. Quality control in cervical cytology. J Clin Pathol. 1974 Dec;27(12):935–944. doi: 10.1136/jcp.27.12.935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kaufman R. H. Dysplasia and carcinoma in situ of the cervix. Clin Obstet Gynecol. 1967 Dec;10(4):748–784. [PubMed] [Google Scholar]
  9. Kirkland J. A., Stanley M. A., Cellier K. M. Comparative study of histologic and chromosomal abnormalities in cervical neoplasia. Cancer. 1967 Nov;20(11):1934–1952. doi: 10.1002/1097-0142(196711)20:11<1934::aid-cncr2820201122>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  10. Koss L. G. Dysplasia. A real concept or a misnomer? Obstet Gynecol. 1978 Mar;51(3):374–379. [PubMed] [Google Scholar]
  11. Nelson J. H., Jr, Averette H. E., Richart R. M. Detection, diagnostic evaluation and treatment of dysplasia, carcinoma in situ and early invasive cervical carcinoma. CA Cancer J Clin. 1979 May-Jun;29(3):174–192. doi: 10.3322/canjclin.29.3.174. [DOI] [PubMed] [Google Scholar]
  12. PAPANICOLAOU G. N. A survey of the actualities and potentialities of exfoliative cytology in cancer diagnosis. Ann Intern Med. 1949 Oct;31(4):661–674. doi: 10.7326/0003-4819-31-4-661. [DOI] [PubMed] [Google Scholar]
  13. RICHART R. M. A RADIOAUTOGRAPHIC ANALYSIS OF CELLULAR PROLIFERATION IN DYSPLASIA AND CARCINOMA IN SITU OF THE UTERINE CERVIX. Am J Obstet Gynecol. 1963 Aug 1;86:925–930. doi: 10.1016/s0002-9378(16)35248-6. [DOI] [PubMed] [Google Scholar]
  14. Richart R. M., Barron B. A. A follow-up study of patients with cervical dysplasia. Am J Obstet Gynecol. 1969 Oct 1;105(3):386–393. doi: 10.1016/0002-9378(69)90268-3. [DOI] [PubMed] [Google Scholar]
  15. Richart R. M. Cervical intraepithelial neoplasia. Pathol Annu. 1973;8:301–328. [PubMed] [Google Scholar]
  16. Richart R. M. Current concepts in obstetrics and gynecology: The patient with an abnormal Pap smear--screening techniques and managment. N Engl J Med. 1980 Feb 7;302(6):332–334. doi: 10.1056/NEJM198002073020606. [DOI] [PubMed] [Google Scholar]
  17. Richart R. M., Lerch V., Barron B. A. A time-lapse cinematographic study in vitro of mitosis in normal human cervical epithelium, dysplasia, and carcinoma in situ. J Natl Cancer Inst. 1967 Sep;39(3):571–577. [PubMed] [Google Scholar]
  18. Riddell R. H., Shove D. C., Ritchie J. K., Lennard-Jones J. E., Morson B. C. Precancer in ulcerative colitis. Major Probl Pathol. 1978;10:95–118. [PubMed] [Google Scholar]
  19. Roche W. D., Norris H. J. Microinvasive carcinoma of the cervix. The significance of lymphatic invasion and confluent patterns of stromal growth. Cancer. 1975 Jul;36(1):180–186. doi: 10.1002/1097-0142(197507)36:1<180::aid-cncr2820360116>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  20. Shingleton H. M., Richart R. M., Wiener J., Spiro D. Human cervical intraepithelial neoplasia: fine structure of dysplasia and carcinoma in situ. Cancer Res. 1968 Apr;28(4):695–706. [PubMed] [Google Scholar]
  21. Spriggs A. I., Boddington M. M. Progression and regression of cervical lesions. Review of smears from women followed without initial biopsy or treatment. J Clin Pathol. 1980 Jun;33(6):517–522. doi: 10.1136/jcp.33.6.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Spriggs A. I., Bowey C. E., Cowdell R. H. Chromosomes of precancerous lesions of thecervix uteri. New data and a review. Cancer. 1971 May;27(5):1239–1254. doi: 10.1002/1097-0142(197105)27:5<1239::aid-cncr2820270532>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  23. Stanbridge C. M., Mather J., Curry A., Butler E. B. Demonstration of papilloma virus particles in cervical and vaginal scrape material: a report of 10 cases. J Clin Pathol. 1981 May;34(5):524–531. doi: 10.1136/jcp.34.5.524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Stanbridge D. M., Butler E. B., Langley F. A. Problems in cervicovaginal cytology: fine structure as an aid to diagnosis. Acta Cytol. 1980 Jul-Aug;24(4):335–343. [PubMed] [Google Scholar]
  25. Wilbanks G. D., Richart R. M., Terner J. Y. DNA content of cervical intraepithelial neoplasia studied by two-wavelength Feulgen cytophotometry. Am J Obstet Gynecol. 1967 Jul 15;98(6):792–799. doi: 10.1016/0002-9378(67)90195-0. [DOI] [PubMed] [Google Scholar]

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