Abstract
The relation of the secretory immunoglobulin system in the colon to colorectal cancer and dysplasia has been examined by staining routine formalin-fixed, paraffin-embedded sections from cases of carcinoma, adenoma and ulcerative colitis for secretory component (SC), IgA and J chain. In carcinomas there was a close relation between SC synthesis and differentiation and a similar relation was apparent between SC synthesis and degrees of dysplasia in adenomas. In both morphological and functional (SC synthesis) terms degrees of dysplasia in adenomas resembled degrees of differentiation in carcinomas suggesting that the essential "switch" in the progression towards neoplasia may occur at the level of the adenoma and that invasive malignancy can arise from dysplastic mucosa of varying severity. Actively regenerating mucosa in ulcerative colitis (UC) showed intense staining for SC as opposed to foci of precancerous dysplasia where, with one exception, staining was markedly reduced or absent, suggesting staining for SC could be useful in identifying foci of precancerous dysplasia in UC. In the absence of severe chronic inflammation, as in UC, the number of IgA-containing plasma cells was closely related to SC staining of neoplastic mucosa suggesting that SC may be important in the mechanism by which IgA lymphocytes home to the lamina propria of the colon.
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- Brandtzaeg P., Gjeruldsen S. T., Korsrud F., Baklien K., Berdal P., Ek J. The human secretory immune system shows striking heterogeneity with regard to involvement of J chain-positive IgD immunocytes. J Immunol. 1979 Feb;122(2):503–510. [PubMed] [Google Scholar]
- Brown W. R. Relationships between immunoglobulins and the intestinal epithelium. Gastroenterology. 1978 Jul;75(1):129–138. [PubMed] [Google Scholar]
- Guy-Grand D., Griscelli C., Vassalli P. Gut-associated lymphoblasts and intestinal IgA plasma cells. Adv Exp Med Biol. 1974;45(0):41–46. doi: 10.1007/978-1-4613-4550-3_5. [DOI] [PubMed] [Google Scholar]
- Isaacson P. Crypt cell carcinoma of the appendix (so-called adenocarcinoid tumor). Am J Surg Pathol. 1981 Apr;5(3):213–224. doi: 10.1097/00000478-198104000-00001. [DOI] [PubMed] [Google Scholar]
- Isaacson P. Immunochemical demonstration of J chain: a marker of B-cell malignancy. J Clin Pathol. 1979 Aug;32(8):802–807. doi: 10.1136/jcp.32.8.802. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Isaacson P., Judd M. A. Immunohistochemistry of carcinoembryonic antigen in the small intestine. Cancer. 1978 Sep;42(3 Suppl):1554–1559. doi: 10.1002/1097-0142(197809)42:3+<1554::aid-cncr2820420830>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
- Isaacson P., Le Vann H. P. The demonstration of carcinoembryonic antigen in colorectal carcinoma and colonic polyps using an immunoperoxidase technique. Cancer. 1976 Sep;38(3):1348–1356. doi: 10.1002/1097-0142(197609)38:3<1348::aid-cncr2820380339>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
- Isaacson P. Tissue demonstration of carcinoembryonic antigen (CEA) in ulcerative colitis. Gut. 1976 Jul;17(7):561–567. doi: 10.1136/gut.17.7.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mepham B. L., Frater W., Mitchell B. S. The use of proteolytic enzymes to improve immunoglobulin staining by the PAP technique. Histochem J. 1979 May;11(3):345–357. doi: 10.1007/BF01005033. [DOI] [PubMed] [Google Scholar]
- Poger M. E., Hirsch B. R., Lamm M. E. Synthesis of secretory component by colonic neoplasms. Am J Pathol. 1976 Feb;82(2):327–338. [PMC free article] [PubMed] [Google Scholar]
- Weisz-Carrington P., Poger M. E., Lamm M. E. Secretory immunoglobulins in colonic neoplasms. Am J Pathol. 1976 Nov;85(2):303–316. [PMC free article] [PubMed] [Google Scholar]