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. 1982 Jan;35(1):26–30. doi: 10.1136/jcp.35.1.26

Morphological and mucus secretion criteria for differential diagnosis of solitary ulcer syndrome and non-specific proctitis.

M Ehsanullah, M I Filipe, B Gazzard
PMCID: PMC497443  PMID: 7061717

Abstract

Over a four-year period 21 cases of solitary ulcer syndrome (SUS) were studied for their clinical, histological, and mucus secretion patterns and compared with histological and mucus secretion patterns of 78 cases of non-specific proctitis collected over the same period. Normal mucus composition was found in non-specific proctitis while abnormalities of mucins with predominance of sialomucins were associated with SUS. Although histology remains the most important investigation in the diagnosis of SUS, mucin changes provide valuable additional evidence.

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Selected References

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  1. Brackett K. A., Townsend S. F. Regeneration of colonic mucosa in the rat. J Morphol. 1980 Feb;163(2):203–215. doi: 10.1002/jmor.1051630208. [DOI] [PubMed] [Google Scholar]
  2. Culling C. F., Reid P. E., Burton J. D., Dunn W. L. A histochemical method of differentiating lower gastrointestinal tract mucin from other mucins in primary or metastatic tumours. J Clin Pathol. 1975 Aug;28(8):656–658. doi: 10.1136/jcp.28.8.656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Culling C. F., Reid P. E., Worth A. J., Dunn W. L. A new histochemical technique of use in the interpretation and diagnosis of adenocarcinoma and villous lesions in the large intestine. J Clin Pathol. 1977 Nov;30(11):1056–1062. doi: 10.1136/jcp.30.11.1056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dawson P. A., Patel J., Filipe M. I. Variations in sialomucins in the mucosa of the large intestine in malignancy: a quantimet and statistical analysis. Histochem J. 1978 Sep;10(5):559–572. doi: 10.1007/BF01003137. [DOI] [PubMed] [Google Scholar]
  5. Filipe M. I., Branfoot A. C. Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma. Cancer. 1974 Aug;34(2):282–290. doi: 10.1002/1097-0142(197408)34:2<282::aid-cncr2820340211>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  6. Filipe M. I. Mucins in the human gastrointestinal epithelium: a review. Invest Cell Pathol. 1979 Jul-Sep;2(3):195–216. [PubMed] [Google Scholar]
  7. Filipe M. I. Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. A morphological and histochemical study. Br J Cancer. 1975 Jul;32(1):60–77. doi: 10.1038/bjc.1975.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Filipe M. I., Mughal S., Bussey H. J. Patterns of mucus secretion in the colonic epithelium in familial polyposis. Invest Cell Pathol. 1980 Oct-Dec;3(4):329–343. [PubMed] [Google Scholar]
  9. Greaves P., Filipe M. I., Branfoot A. C. Transitional mucosa and survival in human colorectal cancer. Cancer. 1980 Aug 15;46(4):764–770. doi: 10.1002/1097-0142(19800815)46:4<764::aid-cncr2820460421>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  10. Isaacson P., Attwood P. R. Failure to demonstrate specificity of the morphological and histochemical changes in mucosa adjacent to colonic carcinoma (transitional mucosa). J Clin Pathol. 1979 Mar;32(3):214–218. doi: 10.1136/jcp.32.3.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kim Y. S., Isaacs R., Perdomo J. M. Alterations of membrane glycopeptides in human colonic adenocarcinoma. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4869–4873. doi: 10.1073/pnas.71.12.4869. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LaMont J. T., Isselbacher K. J. Alterations in glycosyltransferase activity in human colon cancer. J Natl Cancer Inst. 1975 Jan;54(1):53–56. doi: 10.1093/jnci/54.1.53. [DOI] [PubMed] [Google Scholar]
  13. LaMont J. T., Ventola A. Galactosyltransferase in fetal, neonatal, and adult colon: relationship to differentiation. Am J Physiol. 1978 Aug;235(2):E213–E217. doi: 10.1152/ajpendo.1978.235.2.E213. [DOI] [PubMed] [Google Scholar]
  14. Madigan M. R., Morson B. C. Solitary ulcer of the rectum. Gut. 1969 Nov;10(11):871–881. doi: 10.1136/gut.10.11.871. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Neutra M. R., Grand R. J., Trier J. S. Glycoprotein synthesis, transport, and secretion by epithelial cells of human rectal mucosa: normal and cystic fibrosis. Lab Invest. 1977 May;36(5):535–546. [PubMed] [Google Scholar]
  16. O'Gorman T. A., LaMont J. T. Glycoprotein synthesis and secretion in human colon cancers and normal colonic mucosa. Cancer Res. 1978 Sep;38(9):2784–2789. [PubMed] [Google Scholar]
  17. Rhatigan R. M., Saffos R. O. Mucosal hyperplasia in clonic diverticula. Histopathology. 1979 Mar;3(2):153–160. doi: 10.1111/j.1365-2559.1979.tb02990.x. [DOI] [PubMed] [Google Scholar]
  18. Rogers C. M., Cooke K. B., Filipe M. I. Sialic acids of human large bowel mucosa: o-acylated variants in normal and malignant states. Gut. 1978 Jul;19(7):587–592. doi: 10.1136/gut.19.7.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rutter K. R., Riddell R. H. The solitary ulcer syndrome of the rectum. Clin Gastroenterol. 1975 Sep;4(3):505–530. [PubMed] [Google Scholar]
  20. Rutter K. R. Solitary rectal ulcer syndrome. Proc R Soc Med. 1975 Jan;68(1):22–26. doi: 10.1177/003591577506800110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. SPICER S. S. DIAMINE METHODS FOR DIFFERENTIALING MUCOSUBSTANCES HISTOCHEMICALLY. J Histochem Cytochem. 1965 Mar;13:211–234. doi: 10.1177/13.3.211. [DOI] [PubMed] [Google Scholar]
  22. Smith B., Butler M. The autonomic control of colonic mucin secretion in the mouse. Br J Exp Pathol. 1974 Dec;55(6):615–621. [PMC free article] [PubMed] [Google Scholar]
  23. Sprinz H. Factors influencing intestinal cell renewal. A statement of principles. Cancer. 1971 Jul;28(1):71–74. doi: 10.1002/1097-0142(197107)28:1<71::aid-cncr2820280114>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  24. Tutton P. J., Barkla D. H. Neural control of colonic cell proliferation. Cancer. 1980 Mar 15;45(5 Suppl):1172–1177. doi: 10.1002/1097-0142(19800315)45:5+<1172::aid-cncr2820451322>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  25. Warren L., Fuhrer J. P., Buck C. A. Surface glycoproteins of normal and transformed cells: a difference determined by sialic acid and a growth-dependent sialyl transferase. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1838–1842. doi: 10.1073/pnas.69.7.1838. [DOI] [PMC free article] [PubMed] [Google Scholar]

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