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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1982 Jan;35(1):63–68. doi: 10.1136/jcp.35.1.63

Monoclonal gammopathies in the adult population of Finistère, France.

J P Saleun, M Vicariot, P Deroff, J F Morin
PMCID: PMC497449  PMID: 6801095

Abstract

Three hundred and thirty-four monoclonal gammopathies were detected in the sera of 30 279 adults from Finistère. Monoclonal gammopathies (MG) are more common in Finistère than in Paris and their distribution is not homogeneous. IgG paraproteins are particularly common in the northeast of Finistère whereas IgM paraproteins are more common in the southwest. Family studies and the high degree of inbreeding would support the hypothesis that there is a genetic predisposition to develop MG but the occurrence of paraproteins among three non-consanguineous couples seems to favour the existence of an environmental factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson R. E., Ishida K., Li Y., Ishimaru T., Nishiyama H. Geographic aspects of malignant lymphoma and multiple myeloma. Select comparisons involving Japan, England and the United States. Am J Pathol. 1970 Oct;61(1):85–98. [PMC free article] [PubMed] [Google Scholar]
  2. Axelsson U., Bachmann R., Hällén J. Frequency of pathological proteins (M-components) om 6,995 sera from an adult population. Acta Med Scand. 1966 Feb;179(2):235–247. doi: 10.1111/j.0954-6820.1966.tb05453.x. [DOI] [PubMed] [Google Scholar]
  3. Clauvel J. P., Danon F., Seligmann M. Immunoglobulines monoclonales décelées en l'absence de myélome ou de macroglobulinémie de Waldenström. Evolution dans 54 observations. Nouv Rev Fr Hematol. 1971 Sep-Oct;11(5):677–687. [PubMed] [Google Scholar]
  4. Creyssel R., Gibaud A., Cordier J. F., Boissel J. P. The frequency distribution of heavy chain classes and light chain types of 1,000 monoclonal immunoglobulins. Biomedicine. 1975 Jan;22(1):41–48. [PubMed] [Google Scholar]
  5. Derycke C., Fine J. M., Boffa G. A. Dysglobulinémies "essentielles" chez les sujets agés. Nouv Rev Fr Hematol. 1965 Sep-Oct;5(5):729–738. [PubMed] [Google Scholar]
  6. Fateh-Moghadam A., Lamerz R., Knedel M., Tsirimbas B. Elektrophoretische Klassen- und Gruppenverteilung von "Paraproteinen" und normalen Immunglobulinen. Klin Wochenschr. 1971 Apr 15;49(8):458–467. doi: 10.1007/BF01485296. [DOI] [PubMed] [Google Scholar]
  7. Fine J. M., Lambin P., Leroux P. Frequency of monoclonal gammapathy ('M components') in 13,400 sera from blood donors. Vox Sang. 1972;23(4):336–343. doi: 10.1111/j.1423-0410.1972.tb03468.x. [DOI] [PubMed] [Google Scholar]
  8. Fine J. M., Lambin P., Valentin L., Blatrix C. IgG monoclonal gammapathy in the sister of a patient with Waldenström's macroglobulinaemia. Biomedicine. 1973 Mar 20;19(3):117–121. [PubMed] [Google Scholar]
  9. HALLEN J. Frequency of "abnormal" serum globulins (M-components) in the aged. Acta Med Scand. 1963 Jun;173:737–744. [PubMed] [Google Scholar]
  10. Kyle R. A., Finkelstein S., Elveback L. R., Kurland L. T. Incidence of monoclonal proteins in a Minnesota community with a cluster of multiple myeloma. Blood. 1972 Nov;40(5):719–724. [PubMed] [Google Scholar]
  11. Kyle R. A., Heath C. W., Jr, Carbone P. Multiple myeloma in spouses. Arch Intern Med. 1971 May;127(5):944–946. [PubMed] [Google Scholar]
  12. Kyle R. A., Nobrega F. T., Kurland L. T. Multiple myeloma in Olmsted County, Minnesota, 1945-1964. Blood. 1969 May;33(5):739–745. [PubMed] [Google Scholar]
  13. LEWIS E. B. LEUKEMIA, MULTIPLE MYELOMA, AND APLASTIC ANEMIA IN AMERICAN RADIOLOGISTS. Science. 1963 Dec 13;142(3598):1492–1494. doi: 10.1126/science.142.3598.1492. [DOI] [PubMed] [Google Scholar]
  14. Lilienfeld A. M. Epidemiological studies of the leukemogenic effects of radiation. Yale J Biol Med. 1966 Dec;39(3):143–164. [PMC free article] [PubMed] [Google Scholar]
  15. MARTIN N. H. The incidence of myelomatosis. Lancet. 1961 Feb 4;1(7171):237–239. doi: 10.1016/s0140-6736(61)91419-2. [DOI] [PubMed] [Google Scholar]
  16. Meijers K. A., De Leeu M. B., Voormolen-Kălova M. The multiple occurrence of myeloma and asymptomatic paraproteinaemia within one family. Clin Exp Immunol. 1972 Oct;12(2):185–193. [PMC free article] [PubMed] [Google Scholar]
  17. Nishiyama H., Anderson R. E., Ishimaru T., Ishida K., Ii Y., Okabe N. The incidence of malignant lymphoma and multiple myeloma in Hiroshima and Nagasaki atomic bomb survivors, 1945-1965. Cancer. 1973 Dec;32(6):1301–1309. doi: 10.1002/1097-0142(197312)32:6<1301::aid-cncr2820320602>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  18. Odeberg H., Johansson B. G., Berlin S. O. Immunoglobulin analysis in families of myeloma patients. Acta Med Scand. 1974 Nov;196(5):361–367. doi: 10.1111/j.0954-6820.1974.tb01025.x. [DOI] [PubMed] [Google Scholar]
  19. Saleun J. P., Baret M. Paraprotéines monoclonales chez les donneurs de sang du Finistère. Rev Fr Transfus. 1974 Dec;17(4):349–359. doi: 10.1016/s0035-2977(74)80046-5. [DOI] [PubMed] [Google Scholar]
  20. Seligmann M., Danon F., Mihaesco C., Fudenberg H. H. Immunoglobulin abnormalities in families of patients with Waldenström's macroglobulinemia. Am J Med. 1967 Jul;43(1):66–83. doi: 10.1016/0002-9343(67)90149-0. [DOI] [PubMed] [Google Scholar]
  21. Spengler G. A., Bütler R., Fischer C., Ryssel H. J., Schmid E., Siebner H. On the question of familial occurrence of paraproteinemia. Helv Med Acta. 1966 Oct;33(3):208–219. [PubMed] [Google Scholar]
  22. Stalsberg H. Lymphoreticular tumors in Norway and in other European countries. J Natl Cancer Inst. 1973 Jun;50(6):1685–1702. [PubMed] [Google Scholar]
  23. Williams R. C., Jr, Erickson J. L., Polesky H. F., Swaim W. R. Studies of monoclonal immunoglobulins (M-components) in various kindreds. Ann Intern Med. 1967 Aug;67(2):309–327. doi: 10.7326/0003-4819-67-2-309. [DOI] [PubMed] [Google Scholar]
  24. Youinou P., Le Goff P., Saleun J. P., Jouquan J., Tymen G., Le Menn G. Les gammapathies monoclonales. (Revue critique de 219 dossiers colligés en 3 ans). Pathol Biol (Paris) 1977 Oct;25(8):517–521. [PubMed] [Google Scholar]

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