. 2016 Jul 6;8(7):187. doi: 10.3390/v8070187

Table 1.

Recombinant Ranaviruses.

Virus	ORF	Predicted Function	Mutant Phenotype	Reporter Marker	Reference
FV3
	26R	eIF2α homologue	antagonist of PKR; IFN^s; increased apoptosis; reduced pathogenesis	EGFP-puromycin resistance	[44]
	82R	ICP-18	increased apoptosis; increased induction of type I IFN; reduced pathogenesis	EGFP-puromycin resistance	“
	52L	β-hydroxysteroid dehydrogenase homolog	tbd; reduced pathogenesis	EGFP-puromycin resistance	[52]
	64R	caspase activation & recruitment domain-containing (CARD) protein	IFN^s; increased apoptosis; reduced pathogenesis	EGFP-puromycin resistance	“
ATV
	57R	eIF2α homologue	antagonist of PKZ; reduced pathogenesis	neomycin resistance	[27]
	11R	unknown	essential gene	GFP-neomycin resistance	[37]
	25R	RNase III	degrades RNA	GFP-neomycin resistance	“
	40L	CARD-containing gene	tbd; see FV3 above	GFP-neomycin resistance	“
	53R	Unknown—essential	essential gene	GFP-neomycin resistance	“
	54R	unknown	tbd	GFP-neomycin resistance	“
RGV
	53R	viral envelope protein	green virus	EGFP	[56]
	92R	thymidine kinase (TK)	non-essential	EGFP	“
	53R	viral envelope protein	required for viral production; reduced growth when not expressed	IPTG inducible; EGFP	[60]
	2L	viral envelope protein	required for viral production; reduced growth when not expressed	IPTG inducible; EGFP	[61]
	92R67R	TK and deoxyuridine triphosphatase (dUTPase, DUT)		EGFP/RFP	[57]
ESV
	114L	dihydrofolate reductase (DHFR)	non-essential	EGFP-neomycin resistance	[58]
STIV
	VP55	viral envelope protein	green virus	EGFP-VP55 fusion	[43]

tbd = to be determined; IFN^s = interferon sensitivity; “ =same reference as above.