Abstract
Formolised yolk sac antigens of Legionella pneumophila serogroups 1-6 were used to test 1792 serum specimens from 1431 patients with respiratory illness of serological evidence of Legionnaires' disease (LD). Thirty-five patients showed titres against the serogroup 1 antigen diagnostic for LD. Only two further cases were considered to have non-serogroup I infections (both serogroup 4) indicating that such infections are rare. Titres of greater than 1/16 against the serogroup 1 antigen occur in only 3% of subjects without LD and thus the demonstration of such a titre in patients with pneumonia during the early phase of illness can alert the clinician to the likelihood of LD. The supply of serogroup 1 antigen from the Division of Microbiological Reagents and Quality Control to routine diagnostic laboratories will be continued and monovalent serogroup 2-6 antigens will continue to be made available to reference laboratories.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Compston J. E., Horton L. W., Laker M. F., Ayers A. B., Woodhead J. S., Bull H. J., Gazet J. C., Pilkington T. R. Bone disease after jejuno-ileal bypass for obesity. Lancet. 1978 Jul 1;2(8079):1–4. doi: 10.1016/s0140-6736(78)91318-1. [DOI] [PubMed] [Google Scholar]
- Greaves P. W. New methods for the isolation of Legionella pneumophila. J Clin Pathol. 1980 Jun;33(6):581–584. doi: 10.1136/jcp.33.6.581. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lattimer G. L., Cepil B. A. Legionnaires' disease serology. Effect of antigen preparation on specificity and sensitivity of the indirect fluorescent antibody test. J Clin Pathol. 1980 Jun;33(6):585–590. doi: 10.1136/jcp.33.6.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McDade J. E., Shepard C. C., Fraser D. W., Tsai T. R., Redus M. A., Dowdle W. R. Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med. 1977 Dec 1;297(22):1197–1203. doi: 10.1056/NEJM197712012972202. [DOI] [PubMed] [Google Scholar]
- McKinney R. M., Wilkinson H. W., Sommers H. M., Fikes B. J., Sasseville K. R., Yungbluth M. M., Wolf J. S. Legionella pneumophila serogroup six: isolation from cases of legionellosis, identification by immunofluorescence staining, and immunological response to infection. J Clin Microbiol. 1980 Sep;12(3):395–401. doi: 10.1128/jcm.12.3.395-401.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor A. G., Harrison T. G., Dighero M. W., Bradstreet C. M. False positive reactions in the indirect fluorescent antibody test for Legionnaires' disease eliminated by use of formolised yolk-sac antigen. Ann Intern Med. 1979 Apr;90(4):686–689. doi: 10.7326/0003-4819-90-4-686. [DOI] [PubMed] [Google Scholar]
- Taylor A. G., Harrison T. G. Legionnaires' disease caused by Legionella pneumophila serogroup 3. Lancet. 1979 Jul 7;2(8132):47–47. doi: 10.1016/s0140-6736(79)90216-2. [DOI] [PubMed] [Google Scholar]
- Taylor A. G., Harrison T. G. Timing of antibody response in legionnaires' disease. Lancet. 1979 Sep 29;2(8144):697–697. doi: 10.1016/s0140-6736(79)92100-7. [DOI] [PubMed] [Google Scholar]
- Wilkinson H. W., Fikes B. J., Cruce D. D. Indirect immunofluorescence test for serodiagnosis of Legionnaires disease: evidence for serogroup diversity of Legionnaires disease bacterial antigens and for multiple specificity of human antibodies. J Clin Microbiol. 1979 Mar;9(3):379–383. doi: 10.1128/jcm.9.3.379-383.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]