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. 2016 Aug 3;5:F1000 Faculty Rev-1909. [Version 1] doi: 10.12688/f1000research.8881.1

Figure 4. Single molecule analysis of cohesin’s interaction with DNA.

Figure 4.

Purified cohesin incubated with tethered and extended DNA molecules shows the behaviors illustrated 29. The presence of the loader complex (not shown) results in the highly stable interaction of cohesin with DNA. Once loaded, cohesin appears to move freely along the length of the DNA, unless there is an obstacle of greater than ~11 nm in size. Cohesin is released from the untethered end of the DNA molecule (shown at left) and stops when it reaches the tethered end (right).