Abstract
Luminal concentrations of short chain fatty acids (SCFA), ammonia, sodium and potassium were measured in colonic dialysate of 16 control subjects and in 65 cases with ulcerative colitis (UC), which were graded according to mucosal changes into mild (1), moderate (2), or severe (3) inflammatory activity. Sodium concentrations were mildly but not significantly increased in severe ulcerative colitis while luminal potassium concentrations were markedly decreased in severe ulcerative colitis (p less than 0.025). Concentrations of SCFA were increased in severe ulcerative colitis. Butyrate concentrations were significantly raised in all stages of active ulcerative colitis even when other fatty acids were not raised. Of all the parameters a lowered pH and raised butyrate concentration most strikingly correlate with the severity of mucosal change. Results indirectly suggest that control of luminal pH, potassium secretion and utilisation of butyrate by the colonic mucosa are impaired with progressive mucosal inflammation.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown R. L., Gibson J. A., Fenton J. C., Snedden W., Clark M. L., Sladen G. E. Ammonia and urea transport by the excluded human colon. Clin Sci Mol Med. 1975 Apr;48(4):279–287. doi: 10.1042/cs0480279. [DOI] [PubMed] [Google Scholar]
- DUTHIE H. L., WATTS J. M., DEDOMBAL F. T., GOLIGHER J. C. SERUM ELECTROLYTES AND COLONIC TRANSFER OF WATER AND ELECTROLYTES IN CHRONIC ULCERATIVE COLITIS. Gastroenterology. 1964 Nov;47:525–530. [PubMed] [Google Scholar]
- Down P. F., Agostini L., Murison J., Wrong O. M. The interrelations of faecal ammonia, pH and bicarbonate: evidence of colonic absorption of ammonia by non-ionic diffusion. Clin Sci. 1972 Jul;43(1):101–114. doi: 10.1042/cs0430101. [DOI] [PubMed] [Google Scholar]
- Edmonds C. J. Absorption of sodium and water by human rectum measured by a dialysis method. Gut. 1971 May;12(5):356–362. doi: 10.1136/gut.12.5.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harris J., Shields R. Absorption and secretion of water and electrolytes by the intact human colon in diffuse untreated proctocolitis. Gut. 1970 Jan;11(1):27–33. doi: 10.1136/gut.11.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hawker P. C., Mashiter K. E., Turnberg L. A. Mechanisms of transport of Na, Cl, and K in the human colon. Gastroenterology. 1978 Jun;74(6):1241–1247. [PubMed] [Google Scholar]
- Hawker P. C., McKay J. S., Turnberg L. A. Electrolyte transport across colonic mucosa from patients with inflammatory bowel disease. Gastroenterology. 1980 Sep;79(3):508–511. [PubMed] [Google Scholar]
- Henning S. J., Hird F. J. Ketogenesis from butyrate and acetate by the caecum and the colon of rabbits. Biochem J. 1972 Dec;130(3):785–790. doi: 10.1042/bj1300785. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McNeil N. I., Cummings J. H., James W. P. Short chain fatty acid absorption by the human large intestine. Gut. 1978 Sep;19(9):819–822. doi: 10.1136/gut.19.9.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rask-Madsen J. The relationship between sodium fluxes and electrical potentials across the normal and inflamed human rectal wall in vivo. Acta Med Scand. 1973 Oct;194(4):311–317. doi: 10.1111/j.0954-6820.1973.tb19451.x. [DOI] [PubMed] [Google Scholar]
- Roediger W. E., Moore A. Effect of short-chaim fatty acid on sodium absorption in isolated human colon perfused through the vascular bed. Dig Dis Sci. 1981 Feb;26(2):100–106. doi: 10.1007/BF01312224. [DOI] [PubMed] [Google Scholar]
- Roediger W. E. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut. 1980 Sep;21(9):793–798. doi: 10.1136/gut.21.9.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roediger W. E. The colonic epithelium in ulcerative colitis: an energy-deficiency disease? Lancet. 1980 Oct 4;2(8197):712–715. doi: 10.1016/s0140-6736(80)91934-0. [DOI] [PubMed] [Google Scholar]
- Rousseau B., Sladen G. E. Effect of luminal pH on the absorption of water, Na + and Cl-by rat intestine in vivo. Biochim Biophys Acta. 1971 Jun 1;233(3):591–593. doi: 10.1016/0005-2736(71)90157-x. [DOI] [PubMed] [Google Scholar]
- Rubinstein R., Howard A. V., Wrong O. M. In vivo dialysis of faeces as a method of stool analysis. IV. The organic anion component. Clin Sci. 1969 Oct;37(2):549–564. [PubMed] [Google Scholar]
- Ruppin H., Bar-Meir S., Soergel K. H., Wood C. M., Schmitt M. G., Jr Absorption of short-chain fatty acids by the colon. Gastroenterology. 1980 Jun;78(6):1500–1507. [PubMed] [Google Scholar]
- SMIDDY F. G., GREGORY S. D., SMITH I. B., GOLIGHER J. C. Faecal loss of fluid, electrolytes, and nitrogen in colitis before and after ileostomy. Lancet. 1960 Jan 2;1(7114):14–19. doi: 10.1016/s0140-6736(60)92717-3. [DOI] [PubMed] [Google Scholar]
- TRUELOVE S. C., RICHARDS W. C. Biopsy studies in ulcerative colitis. Br Med J. 1956 Jun 9;1(4979):1315–1318. doi: 10.1136/bmj.1.4979.1315. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WRONG O., METCALFE-GIBSON A., MORRISON R. B., NG S. T., HOWARD A. V. IN VIVO DIALYSIS OF FAECES AS A METHOD OF STOOL ANALYSIS. I. TECHNIQUE AND RESULTS IN NORMAL SUBJECTS. Clin Sci. 1965 Apr;28:357–375. [PubMed] [Google Scholar]