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. 1982 Mar;35(3):327–337. doi: 10.1136/jcp.35.3.327

Combined immunological and histochemical analysis of skin and lymph node lesions in histiocytosis X.

J A Thomas, G Janossy, M Chilosi, J Pritchard, J R Pincott
PMCID: PMC497540  PMID: 6175664

Abstract

The immunological phenotype of the cells involved in skin and lymph node lesions from two cases of histiocytosis X (H-X) were analysed by immunofluorescence techniques using combinations of heterologous and monoclonal antisera to Ia-like antigen and human cortical thymocyte (HTA-1) determinant. These cells were also characterised by a new technique using simultaneous immunofluorescence and enzyme histochemistry for acid phosphatase (ACPase). The major cell type in the lesions was found to express the same Ia+, HTA-1+ phenotype as normal epidermal Langerhans' cells (LC) and was unreactive for ACPase. Additional cell types included Ia-, HTA-1- multinucleate giant cells and residual lymphoid populations. These findings endorse previous concepts that H-X is a proliferation of abnormal LC and emphasise the heterogeneous nature of the cells involved in the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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