Abstract
Tissue concentrations of histamine have been estimated in peroral duodenal biopsy specimens from five children with coeliac disease while on a gluten-free diet and after a three-month gluten challenge. Histamine concentrations in the patients on a diet did not differ significantly from a group of control children. However after gluten challenge, histological relapse of the duodenal mucosa in each patient was associated with increased tissue concentrations of histamine. The findings suggest that histamine may be involved in the pathogenesis of the small intestinal mucosal changes in children with coeliac disease.
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Selected References
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- ANDERSON C. M., LANGFORD R. F. Bacterial content of small intestine of children in health, in coeliac disease, and in fibrocystic disease of pancreas. Br Med J. 1958 Apr 5;1(5074):803–806. doi: 10.1136/bmj.1.5074.803. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Challacombe D. N., Dawkins P. D., Baker P. Increased tissue concentrations of 5-hydroxytryptamine in the duodenal mucosa of patients with coeliac disease. Gut. 1977 Nov;18(11):882–886. doi: 10.1136/gut.18.11.882. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dollberg L., Gurevitz M., Freier S. Gastrointestinal mast cells in health, and in coeliac disease and other conditions. Arch Dis Child. 1980 Sep;55(9):702–705. doi: 10.1136/adc.55.9.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHORE P. A., BURKHALTER A., COHN V. H., Jr A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther. 1959 Nov;127:182–186. [PubMed] [Google Scholar]
- Trier J. S., Browning T. H. Epithelial-cell renewal in cultured duodenal biopsies in celiac sprue. N Engl J Med. 1970 Dec 3;283(23):1245–1250. doi: 10.1056/NEJM197012032832302. [DOI] [PubMed] [Google Scholar]
- Tutton P. J. The influence of histamine on epithelial cell proliferation in the jejunum of the rat. Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):369–373. doi: 10.1111/j.1440-1681.1976.tb00613.x. [DOI] [PubMed] [Google Scholar]