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. 1982 Jun;35(6):673–680. doi: 10.1136/jcp.35.6.673

Anticoagulant antibodies in the synovial membranes of patients suffering from haemophilia, rheumatoid arthritis and other rheumatic disorders.

S G Rainsford, A Aronstam, E J Holborow, D S McLellan
PMCID: PMC497748  PMID: 6806334

Abstract

This study has identified IgG and IgM anticoagulant antibodies in the synovial membranes of patients suffering from haemophilia and rheumatoid arthritis (RA) but not in synovial tissues from normal subjects or in patients with other arthritides. In the majority of cases the antibody appeared to have the specificity of the lupus-like anticoagulant (LLA) seen in patients with systemic lupus erythematosus (SLE). The importance of these findings with regard to the treatment of certain cases of haemophilia and RA and the possible relation between the presence of these antibodies and viral infections is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Biggs R., Spooner R. J. Haemophilia Centre Director's annual statistics for 1975. Br J Haematol. 1977 Jul;36(3):447–449. doi: 10.1111/j.1365-2141.1977.tb00668.x. [DOI] [PubMed] [Google Scholar]
  2. Bird P. Coagulation in an agarose gel and its application to the detection and measurement of factor VIII antibodies. Br J Haematol. 1975 Feb;29(2):329–340. doi: 10.1111/j.1365-2141.1975.tb01827.x. [DOI] [PubMed] [Google Scholar]
  3. Boxer M., Ellman L., Carvalho A. The lupus anticoagulant. Arthritis Rheum. 1976 Nov-Dec;19(6):1244–1248. doi: 10.1002/art.1780190603. [DOI] [PubMed] [Google Scholar]
  4. Gandolfo G. M., Afeltra A., Amoroso A., Biancolella F., Ferri G. M. Circulating anticoagulant against Factor XII and platelet antibodies in systemic lupus erythematosus. Acta Haematol. 1977;57(3):135–142. doi: 10.1159/000207872. [DOI] [PubMed] [Google Scholar]
  5. Hjelm H. Isolation of IgG3 from normal human sera and from a patient with multiple myeloma by using protein A-sepharose 4B. Scand J Immunol. 1975;4(7):633–640. doi: 10.1111/j.1365-3083.1975.tb02671.x. [DOI] [PubMed] [Google Scholar]
  6. Leone G., Accorra F., Boni P. Circulating anticoagulant against factor XI and thrombocytopenia with platelet aggregation inhibition in systemic lupus erythematosus. Acta Haematol. 1977;58(4):240–245. doi: 10.1159/000207834. [DOI] [PubMed] [Google Scholar]
  7. Levo Y., Gorevic P. D., Kassab H. J., Zucker-Franklin D., Franklin E. C. Association between hepatitis B virus and essential mixed cryoglobulinemia. N Engl J Med. 1977 Jun 30;296(26):1501–1504. doi: 10.1056/NEJM197706302962605. [DOI] [PubMed] [Google Scholar]
  8. PLOTZ C. M., SINGER J. M. The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med. 1956 Dec;21(6):888–892. [PubMed] [Google Scholar]
  9. Poston R. N. A buffered chromic chloride method of attaching antigens to red cells: use in haemagglutination. J Immunol Methods. 1974 May;5(1):91–96. doi: 10.1016/0022-1759(74)90050-7. [DOI] [PubMed] [Google Scholar]
  10. Rainsford S. G., Hall A. Clinical observations and their relationship to laboratory findings in the haemophilias. Thromb Diath Haemorrh. 1975 Dec 15;34(3):734–739. [PubMed] [Google Scholar]
  11. Rainsford S. G., Hall A. Letter: Detection and measurement of factor VIII antibodies in an agarose gel: a modified method. Br J Haematol. 1976 Jun;33(2):309–309. doi: 10.1111/j.1365-2141.1976.tb03543.x. [DOI] [PubMed] [Google Scholar]
  12. Rizza C. R., Biggs R. The treatment of patients who have factor-VIII antibodies. Br J Haematol. 1973 Jan;24(1):65–82. doi: 10.1111/j.1365-2141.1973.tb05728.x. [DOI] [PubMed] [Google Scholar]
  13. Shapiro S. S. Antibodies to blood coagulation factors. Clin Haematol. 1979 Feb;8(1):207–214. [PubMed] [Google Scholar]

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