Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1982 Jul;35(7):740–743. doi: 10.1136/jcp.35.7.740

Platelet inhibition with Ticlopidine in atherosclerotic intermittent claudication.

A Aukland, R A Hurlow, A J George, J Stuart
PMCID: PMC497768  PMID: 7047575

Abstract

Fifty-one men with atherosclerotic intermittent claudication and haemorheological abnormalities completed a double-blind, one-year randomised trial of Ticlopidine (500 mg/day), a new antiplatelet agent. Ticlopidine caused significant inhibition of platelet aggregation but did not fully correct abnormalities of coagulation, viscosity, and fibrinolysis. There was no significant improvement in walking ability, Doppler ankle-pressure indices, or calf blood flow. Sustained platelet inhibition for 12 months was insufficient to correct the prothrombotic abnormality of extensive atherosclerosis.

Full text

PDF
740

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashida S. I., Abiko Y. Mode of action of ticlopidine in inhibition of platelet aggregation in the rat. Thromb Haemost. 1979 Apr 23;41(2):436–449. [PubMed] [Google Scholar]
  2. Blunt R. J., George A. J., Hurlow R. A., Strachan C. J., Stuart J. Hyperviscosity and thrombotic changes in idiopathic and secondary Raynaud's syndrome. Br J Haematol. 1980 Aug;45(4):651–658. doi: 10.1111/j.1365-2141.1980.tb07188.x. [DOI] [PubMed] [Google Scholar]
  3. Browse N. L., Gray L., Jarrett P. E., Morland M. Blood and vein-wall fibrinolytic activity in health and vascular disease. Br Med J. 1977 Feb 19;1(6059):478–481. doi: 10.1136/bmj.1.6059.478. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cella G., Zahavi J., de Haas H. A., Kakkar V. V. beta-Thromboglobulin, platelet production time and pletelet function in vascular disease. Br J Haematol. 1979 Sep;43(1):127–136. doi: 10.1111/j.1365-2141.1979.tb03727.x. [DOI] [PubMed] [Google Scholar]
  5. Clyne C. A., Galland R. B., Fox M. J., Gustave R., Jantet G. H., Jamieson C. W. A controlled trial of naftidrofuryl (Praxilene) in the treatment of intermittent claudication. Br J Surg. 1980 May;67(5):347–348. doi: 10.1002/bjs.1800670515. [DOI] [PubMed] [Google Scholar]
  6. Conard J., Lecrubier C., Scarabin P. Y., Horellou M. H., Samama M., Bousser M. G. Effects of long term administration of ticlopidine on platelet function and hemostatic variables. Thromb Res. 1980 Oct 1;20(1):143–148. doi: 10.1016/0049-3848(80)90064-x. [DOI] [PubMed] [Google Scholar]
  7. Dormandy J. A., Hoare E., Colley J., Arrowsmith D. E., Dormandy T. L. Clinical, haemodynamic, rheological, and biochemical findings in 126 patients with intermittent claudication. Br Med J. 1973 Dec 8;4(5892):576–581. doi: 10.1136/bmj.4.5892.576. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hutchinson R. M., Eastham R. D. A comparison of the erythrocyte sedimentation rate and plasma viscosity in detecting changes in plasma proteins. J Clin Pathol. 1977 Apr;30(4):345–349. doi: 10.1136/jcp.30.4.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Knudsen J. B., Gormsen J. The effect of ticlopidine on platelet function in normal volunteers and in patients with platelet hyperaggregability in vitro. Thromb Res. 1979;16(5-6):663–671. doi: 10.1016/0049-3848(79)90210-x. [DOI] [PubMed] [Google Scholar]
  10. MURPHY E. A., MUSTARD J. F. Coagulation tests and platelet economy in atherosclerotic and control subjects. Circulation. 1962 Jan;25:114–125. doi: 10.1161/01.cir.25.1.114. [DOI] [PubMed] [Google Scholar]
  11. Meade T. W., North W. R., Chakrabarti R., Stirling Y., Haines A. P., Thompson S. G., Brozovié M. Haemostatic function and cardiovascular death: early results of a prospective study. Lancet. 1980 May 17;1(8177):1050–1054. doi: 10.1016/s0140-6736(80)91498-1. [DOI] [PubMed] [Google Scholar]
  12. NAIMI S., GOLDSTEIN R., PROGER S. Studies of coagulation and fibrinolysis of the arterial and venous blood in normal subjects and patients with atherosclerosis. Circulation. 1963 May;27:904–918. doi: 10.1161/01.cir.27.5.904. [DOI] [PubMed] [Google Scholar]
  13. NESTEL P. J. Fibrinolytic activity of the blood in intermittent claudication. Lancet. 1959 Sep 19;2(7099):373–374. doi: 10.1016/s0140-6736(59)91637-x. [DOI] [PubMed] [Google Scholar]
  14. O'Brien J. R., Etherington M. D., Jamieson S., Lawford P., Lincoln S. V., Alkjaersig N. J. Blood changes in atherosclerosis and long after myocardial infarction and venous thrombosis. Thromb Diath Haemorrh. 1975 Nov 15;34(2):483–497. [PubMed] [Google Scholar]
  15. O'Brien J. R., Etherington M. D., Shuttleworth R. D. Ticlopidine - an antiplatelet drug: effects in human volunteers. Thromb Res. 1978 Aug;13(2):245–254. doi: 10.1016/0049-3848(78)90012-9. [DOI] [PubMed] [Google Scholar]
  16. Stuart J., George A. J., Davies A. J., Aukland A., Hurlow R. A. Haematological stress syndrome in atherosclerosis. J Clin Pathol. 1981 May;34(5):464–467. doi: 10.1136/jcp.34.5.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stuart J., Kenny M. W. Blood rheology. J Clin Pathol. 1980 May;33(5):417–429. doi: 10.1136/jcp.33.5.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Thebault J. J., Blatrix C. E., Blanchard J. F., Panak E. A. Effects of ticlopidine, a new platelet aggregation inhibitor in man. Clin Pharmacol Ther. 1975 Oct;18(4):485–490. doi: 10.1002/cpt1975184485. [DOI] [PubMed] [Google Scholar]
  19. Ward A. S., Porter N., Preston F. E., Morris-Jones W. Platelet aggregation in patients with peripheral vascular disease. Atherosclerosis. 1978 Jan;29(1):63–68. doi: 10.1016/0021-9150(78)90094-1. [DOI] [PubMed] [Google Scholar]
  20. Waters K. J., Craxford A. D., Chamberlain J. The effect of naftidrofuryl (Praxilene) on intermittent claudication. Br J Surg. 1980 May;67(5):349–351. doi: 10.1002/bjs.1800670516. [DOI] [PubMed] [Google Scholar]
  21. Yao S. T., Hobbs J. T., Irvine W. T. Ankle systolic pressure measurements in arterial disease affecting the lower extremities. Br J Surg. 1969 Sep;56(9):676–679. doi: 10.1002/bjs.1800560910. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES