Abstract
This paper describes a five year follow-up study of the incidence and course of gastritis affecting the antrum and body of the stomach of 50 patients, most of whom presented with non-ulcer dyspepsia and a few with peptic ulceration. We have shown that antral gastritis, like gastritis affecting the fundus, becomes more severe in a proportion of patients as time goes by. Perhaps more important is the increased severity and progression of atrophic and metaplastic change in the antrum compared with the fundus. The significance of these changes with regard to the development of peptic ulceration and malignancy is discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Delaney J. P., Broadie T. A., Robbins P. L. Pyloric reflux gastritis: the offending agent. Surgery. 1975 Jun;77(6):764–772. [PubMed] [Google Scholar]
- Gear M. W., Truelove S. C., Whitehead R. Gastric ulcer and gastritis. Gut. 1971 Aug;12(8):639–645. doi: 10.1136/gut.12.8.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hebbel R. Chronic Gastritis: Its Relation to Gastric and Duodenal Ulcer and to Gastric Carcinoma. Am J Pathol. 1943 Jan;19(1):43–71. [PMC free article] [PubMed] [Google Scholar]
- MORSON B. C. Carcinoma arising from areas of intestinal metaplasia in the gastric mucosa. Br J Cancer. 1955 Sep;9(3):377–385. doi: 10.1038/bjc.1955.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts D. M. Chronic gastritis, alcohol, and non-ulcer dyspepsia. Gut. 1972 Oct;13(10):768–774. doi: 10.1136/gut.13.10.768. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SIURALA M., SEPPALA K. Atrophic gastritis as a possible precursor of gastric carcinoma and pernicious anemia. Results of follow-up examinations. Acta Med Scand. 1960 May 5;166:455–474. doi: 10.1111/j.0954-6820.1960.tb17401.x. [DOI] [PubMed] [Google Scholar]
- Siurala M., Salmi H. J. Long-term follow-up of subjects with superficial gastritis or a normal gastric mucosa. Scand J Gastroenterol. 1971;6(5):459–463. doi: 10.3109/00365527109180726. [DOI] [PubMed] [Google Scholar]
- Siurala M., Varis K., Wiljasalo M. Studies of patients with atrophic gastritis: a 10-15-year follow-up. Scand J Gastroenterol. 1966;1(1):40–48. doi: 10.1080/00365521.1966.11800612. [DOI] [PubMed] [Google Scholar]
- Stalsberg H., Taksdal S. Stomach cancer following gastric surgery for benign conditions. Lancet. 1971 Nov 27;2(7735):1175–1177. doi: 10.1016/s0140-6736(71)90489-2. [DOI] [PubMed] [Google Scholar]
- Strickland R. G., Mackay I. R. A reappraisal of the nature and significance of chronic atrophic gastritis. Am J Dig Dis. 1973 May;18(5):426–440. doi: 10.1007/BF01071995. [DOI] [PubMed] [Google Scholar]
- Vandelli C., Bottazzo G. F., Doniach D., Franceschi F. Autoantibodies to gastrin-producing cells in antral (type B) chronic gastritis. N Engl J Med. 1979 Jun 21;300(25):1406–1410. doi: 10.1056/NEJM197906213002502. [DOI] [PubMed] [Google Scholar]
- Whitehead R., Truelove S. C., Gear M. W. The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens. J Clin Pathol. 1972 Jan;25(1):1–11. doi: 10.1136/jcp.25.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]