Abstract
The histological findings and the number of immunoglobulin-containing cells in gastric and duodenal biopsies from patients with Crohn's disease of the large or small bowel, or both, with and without upper gastrointestinal complaints, are reported and compared with those of healthy controls and patients with chronic non-specific gastritis and duodenitis. The gastric and duodenal biopsies from patients with Crohn's disease showed a higher incidence of chronic non-specific inflammation and a significant increase of IgM-containing cells compared with healthy controls. The increase of IgM-containing cells in the lamina propria cannot be explained by the high incidence of chronic non-specific inflammation, a condition shown to have increased numbers of IgM-containing cells as well, since patients with Crohn's disease of the ileum or colon, or both, without histological abnormalities of the gastric and duodenal mucosa also showed an increase of IgM-containing cells. It is concluded that both the high incidence of chronic non-specific inflammation in gastric and duodenal biopsies and the increased number of IgM-containing cells are an expression of Crohn's disease as a systemic disorder of the gastrointestinal tract.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bosman F. T., Lindeman J., Kuiper G., van der Wal A., Kreunig J. The influence of fixation on immunoperoxidase staining of plasmacells in paraffin sections of intestinal biopsy specimens. Histochemistry. 1977 Jul 18;53(1):57–62. doi: 10.1007/BF00511210. [DOI] [PubMed] [Google Scholar]
- Brandtzaeg P., Baklien K., Fausa O., Hoel P. S. Immunohistochemical characterization of local immunoglobulin formation in ulcerative colitis. Gastroenterology. 1974 Jun;66(6):1123–1136. [PubMed] [Google Scholar]
- Brandtzaeg P., Baklien K. Immunohistochemical studies of the formation and epithelial transport of immunoglobulins in normal and diseased human intestinal mucosa. Scand J Gastroenterol Suppl. 1976;36:1–45. [PubMed] [Google Scholar]
- Heyworth M. F. Influence of two different fixatives on the identification of plasma cells in human rectal mucosa. J Histochem Cytochem. 1980 Sep;28(9):1018–1020. doi: 10.1177/28.9.6157713. [DOI] [PubMed] [Google Scholar]
- Korelitz B. I., Present D. H., Alpert L. I., Marshak R. H., Janowitz H. D. Recurrent regional ileitis after ileostomy and colectomy for granulomatous colitis. N Engl J Med. 1972 Jul 20;287(3):110–115. doi: 10.1056/NEJM197207202870302. [DOI] [PubMed] [Google Scholar]
- Kreuning J., Bosman F. T., Kuiper G., Wal A. M., Lindeman J. Gastric and duodenal mucosa in 'healthy' individuals. An endoscopic and histopathological study of 50 volunteers. J Clin Pathol. 1978 Jan;31(1):69–77. doi: 10.1136/jcp.31.1.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meijer C. J., Bosman F. T., Lindeman J. Evidence for predominant involvement of the B-cell system in the inflammatory process in Crohn's disease. Scand J Gastroenterol. 1979;14(1):21–32. doi: 10.3109/00365527909179842. [DOI] [PubMed] [Google Scholar]
- Piris J., Thomas N. D. A quantitative study of the influence of fixation on immunoperoxidase staining of rectal mucosal plasma cells. J Clin Pathol. 1980 Apr;33(4):361–364. doi: 10.1136/jcp.33.4.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rosekrans P. C., Meijer C. J., van der Wal A. M., Cornelisse C. J., Lindeman J. Immunoglobulin containing cells in inflammatory bowel disease of the colon: a morphometric and immunohistochemical study. Gut. 1980 Nov;21(11):941–947. doi: 10.1136/gut.21.11.941. [DOI] [PMC free article] [PubMed] [Google Scholar]