Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1982 Oct;35(10):1086–1091. doi: 10.1136/jcp.35.10.1086

6-Thioguanine as a cause of toxic veno-occlusive disease of the liver

MB Satti 1,2,3, K Weinbren 1,2,3, EC Gordon-Smith 1,2,3
PMCID: PMC497888  PMID: 6957419

Abstract

Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinoside in the second patient.

Full text

PDF
1086

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berk P. D., Popper H., Krueger G. R., Decter J., Herzig G., Graw R. G., Jr Veno-occlusive disease of the liver after allogeneic bone marrow transplantation: possible association with graft-versus-host disease. Ann Intern Med. 1979 Feb;90(2):158–164. doi: 10.7326/0003-4819-90-2-158. [DOI] [PubMed] [Google Scholar]
  2. Espiritu C. R., Alalu J., Glueckauf L. G., Lubin J. Allopurinol-induced granulomatous hepatitis. Am J Dig Dis. 1976 Sep;21(9):804–806. doi: 10.1007/BF01073035. [DOI] [PubMed] [Google Scholar]
  3. Griner P. F., Elbadawi A., Packman C. H. Veno-occlusive disease of the liver after chemotherapy of acute leukemia. Report of two cases. Ann Intern Med. 1976 Nov;85(5):578–582. doi: 10.7326/0003-4819-85-5-578. [DOI] [PubMed] [Google Scholar]
  4. Jacobs P., Miller J. L., Uys C. J., Dietrich B. E. Fatal veno-occlusive disease of the liver after chemotherapy, whole-body irradiation and bone marrow transplantation for refractory acute leukaemia. S Afr Med J. 1979 Jan 6;55(1):5–10. [PubMed] [Google Scholar]
  5. Lewin K., Millis R. R. Human radiation hepatitis. A morphologic study with emphasis on the late changes. Arch Pathol. 1973 Jul;96(1):21–26. [PubMed] [Google Scholar]
  6. Lyford C. L., Vergara G. G., Moeller D. D. Hepatic veno-occlusive disease originating in Ecuador. Gastroenterology. 1976 Jan;70(1):105–108. [PubMed] [Google Scholar]
  7. MEACHAM G. C., TILLOTSON F. W., HEINLE R. W. Liver damage after prolonged urethane therapy. Am J Clin Pathol. 1952 Jan;22(1):22–27. doi: 10.1093/ajcp/22.1.22. [DOI] [PubMed] [Google Scholar]
  8. Marubbio A. T., Danielson B. Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine. Gastroenterology. 1975 Sep;69(3):739–743. [PubMed] [Google Scholar]
  9. PARKER R. G. Occlusion of the hepatic veins in man. Medicine (Baltimore) 1959 Dec;38:369–402. doi: 10.1097/00005792-195912000-00002. [DOI] [PubMed] [Google Scholar]
  10. Penta J. S., Von Hoff D. D., Muggia F. M. Hepatotoxicity of combination chemotherapy for acute myelocytic leukemia. Ann Intern Med. 1977 Aug;87(2):247–248. doi: 10.7326/0003-4819-87-2-247_2. [DOI] [PubMed] [Google Scholar]
  11. Pittillo R. F., Woolley C. Disposition of arabinosylcytosine (NSC-63878) and 6-THIOGUANINE (NSC-752) in solid L1210 leukemia tumor-bearing mice. Cancer Chemother Rep. 1973 Sep-Oct;57(3):275–289. [PubMed] [Google Scholar]
  12. Reed G. B., Jr, Cox A. J., Jr The human liver after radiation injury. A form of veno-occlusive disease. Am J Pathol. 1966 Apr;48(4):597–611. [PMC free article] [PubMed] [Google Scholar]
  13. Simmons F., Feldman B., Gerety D. Granulomatous hepatitis in a patient receiving allopurinol. Gastroenterology. 1972 Jan;62(1):101–104. [PubMed] [Google Scholar]
  14. Sloane J. P., Farthing M. J., Powles R. L. Histopathological changes in the liver after allogeneic bone marrow transplantation. J Clin Pathol. 1980 Apr;33(4):344–350. doi: 10.1136/jcp.33.4.344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Underwood J. C., Shahani R. T., Blackburn E. K. Jaundice after treatment of leukemia with busulphan. Br Med J. 1971 Mar 6;1(5748):556–557. doi: 10.1136/bmj.1.5748.556-b. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES