Abstract
The numbers of alpha-naphthyl acetate esterase (ANAE)-positive cells (other than T cells) have been counted in 32 specimens of Hodgkin's disease and two specimens of histiocytic lymphoma. The different Rye subtypes of Hodgkin's disease contain varying numbers of enzyme-positive cells, ranging from 1.8-16% in the lymphocyte-predominant form to 39.8-47% in lymphocyte-depleted Hodgkin's disease. The percentage of enzyme-positive cells in the mixed cellularity variety was from only 6.5 to 14.6%. In the two specimens of apparently genuine histiocytic lymphoma, the enzyme-positive cells constituted 95.2 and 97.5% respectively of all cells. Thus, the numbers of macrophages and macrophage-like cells in true histiocytic lymphoma are much greater than in Hodgkin's disease.
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- BRAUNSTEIN H., FREIMAN D. G., THOMAS W., Jr, GALL E. A. A histochemical study of the enzymatic activity of lymph nodes. III. Granulomatous and primary neoplastic conditions of lymphoid tissue. Cancer. 1962 Jan-Feb;15:139–152. doi: 10.1002/1097-0142(196201/02)15:1<139::aid-cncr2820150120>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
- Crocker J., Jones E. L., Curran R. C. A quantitative study of alpha-naphthyl acetate esterase-positive cells in non-Hodgkin's lymphomas and reactive lymph nodes. J Clin Pathol. 1982 Oct;35(10):1066–1068. doi: 10.1136/jcp.35.10.1066. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crocker J. The enzyme histochemistry of lymphoid and non-lymphoid cells of the human palatine tonsil: a basis for the study of lymphomas. J Pathol. 1981 May;134(1):81–95. doi: 10.1002/path.1711340109. [DOI] [PubMed] [Google Scholar]
- Curran R. C., Jones E. L. Hodgkin's disease: an immunohistochemical and histological study. J Pathol. 1978 May;125(1):39–51. doi: 10.1002/path.1711250107. [DOI] [PubMed] [Google Scholar]
- DORFMAN R. F. Enzyme histochemistry of the cells in Hodgkin's disease and allied disorders. Nature. 1961 Jun 3;190:925–926. doi: 10.1038/190925a0. [DOI] [PubMed] [Google Scholar]
- Katz D. R. The macrophage in Hodgkin's disease. J Pathol. 1981 Feb;133(2):145–159. doi: 10.1002/path.1711330206. [DOI] [PubMed] [Google Scholar]
- Livesey A. E., Sutherland F. I., Brown R. A., Beck J. S., Macgillivray J. B., Slidders W. Cytological basis of histological typing of diffuse Hodgkin's disease. Demonstration of an implied misnomer in the terminology of the Rye classification. J Clin Pathol. 1978 Jun;31(6):551–559. doi: 10.1136/jcp.31.6.551. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Livesey A. E., Sutherland F. I., Brown R. A., Beck J. S., Macgillivray J. B., Slidders W. Cytological basis of histological typing of diffuse Hodgkin's disease. Demonstration of an implied misnomer in the terminology of the Rye classification. J Clin Pathol. 1978 Jun;31(6):551–559. doi: 10.1136/jcp.31.6.551. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mueller J., Brun del Re G., Buerki H., Keller H. U., Hess M. W., Cottier H. Nonspecific acid esterase activity: a criterion for differentiation of T and B lymphocytes in mouse lymph nodes. Eur J Immunol. 1975 Apr;5(4):270–274. doi: 10.1002/eji.1830050411. [DOI] [PubMed] [Google Scholar]
- Nanba K., Itagaki T., Iijima S. Enzyme histochemical investigations of human malignant lymphomas. Beitr Pathol. 1975;154(3):233–242. doi: 10.1016/s0005-8165(75)80032-1. [DOI] [PubMed] [Google Scholar]