Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1982 Dec;35(12):1312–1315. doi: 10.1136/jcp.35.12.1312

Polycythaemia rubra vera and hairy cell leukaemia in the same patient: studies on the spleen

GJ Mufti *, TJ Hamblin *, FK Stevenson *, M Fitchett †
PMCID: PMC497968  PMID: 7174843

Abstract

The first association of polycythaemia rubra vera (PRV) and hairy cell leukaemia (HCL) is reported. The secretion by spleen cells in short term culture of IfGλ to the exclusion κ demonstrated that despite aberrant surface marker studies the HCL was a monoclonal tumour of B cells. Chromosomal studies on splenic cells were not able to demonstrate the common clonal origin of the two tumours.

Full text

PDF
1312

Images in this article

1313Image
on p.1313

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRODY J. I., BEIZER L. H., SCHWARTZ S. MULTIPLE MYELOMA AND THE MYELOPROLIFERATIVE SYNDROMES. Am J Med. 1964 Feb;36:315–319. doi: 10.1016/0002-9343(64)90094-4. [DOI] [PubMed] [Google Scholar]
  2. Bernheim A., Berger R., Preud'homme J. L., Labaume S., Bussel A., Barot-Ciorbaru R. Philadelphia chromosome positive blood B lymphocytes in chronic myelocytic leukemia. Leuk Res. 1981;5(4-5):331–339. doi: 10.1016/0145-2126(81)90005-9. [DOI] [PubMed] [Google Scholar]
  3. Hannam-Harris A. C., Gordon J., Smith J. L. Immunoglobulin synthesis by neoplastic B lymphocytes: free light chain synthesis as a marker of B cell differentiation. J Immunol. 1980 Nov;125(5):2177–2181. [PubMed] [Google Scholar]
  4. Heinle E. W., Jr, Sarasti H. O., Garcia D., Kenny J. J., Westerman M. P. Polycythemia vera associated with lymphomatous diseases and myeloma. Arch Intern Med. 1966 Oct;118(4):351–355. [PubMed] [Google Scholar]
  5. Kearney L., Orchard K. H., Hibbin J., Goldman J. M. T-cell cytogenetics in chronic granulocytic leukaemia. Lancet. 1982 Apr 10;1(8276):858–858. doi: 10.1016/s0140-6736(82)91912-2. [DOI] [PubMed] [Google Scholar]
  6. LAWRENCE J. H., ROSENTHAL R. L. Multiple myeloma associated with polycythemia; report of four cases. Am J Med Sci. 1949 Aug;218(2):149–154. doi: 10.1097/00000441-194908000-00005. [DOI] [PubMed] [Google Scholar]
  7. Landaw S. A. Acute leukemia in polycythemia vera. Semin Hematol. 1976 Jan;13(1):33–48. [PubMed] [Google Scholar]
  8. Manoharan A., Catovsky D., Clein P., Traub N. E., Costello C., O'Brien M., Boralessa H., Galton D. A. Simultaneous or spontaneous occurrence of lympho- and myeloproliferative disorders: a report of four cases. Br J Haematol. 1981 May;48(1):111–116. doi: 10.1111/j.1365-2141.1981.00111.x. [DOI] [PubMed] [Google Scholar]
  9. Manoharan A., Catovsky D., Clein P., Traub N. E., Costello C., O'Brien M., Boralessa H., Galton D. A. Simultaneous or spontaneous occurrence of lympho- and myeloproliferative disorders: a report of four cases. Br J Haematol. 1981 May;48(1):111–116. doi: 10.1111/j.1365-2141.1981.00111.x. [DOI] [PubMed] [Google Scholar]
  10. Stevenson F. K., Hamblin T. J., Stevenson G. T., Tutt A. L. Extracellular idiotypic immunoglobulin arising from human leukemic B lymphocytes. J Exp Med. 1980 Dec 1;152(6):1484–1496. doi: 10.1084/jem.152.6.1484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Taberner D. A., Chang J., Otridge B. W. Co-existent chronic lymphatic leukaemia with polycythaemia vera. Postgrad Med J. 1977 Apr;53(618):222–223. doi: 10.1136/pgmj.53.618.222. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES