Abstract
Two cases in which macroglobulinaemia was associated with intestinal lymphangiectasia are recorded. Immunoperoxidase stains demonstrated a high content of monoclonal IgM in the intestinal lymph. The seven previously recorded examples of this association are reviewed. It is concluded that the concurrence of these two conditions is not merely fortuitous, and that increased viscosity of the lymph consequent on its high IgM content may be important in the pathogenesis of the intestinal lymphangiectasia.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bedine M. S., Yardley J. H., Elliott H. L., Banwell J. G., Hendrix T. R. Intestinal involvement in Waldenstrom's macroglobulinemia. Gastroenterology. 1973 Aug;65(2):308–315. [PubMed] [Google Scholar]
- Beker S., Grases P. J., Merino F., Arends T., Guevara J. Intestinal malabsorption in macroglobulinemia. Am J Dig Dis. 1971 Jul;16(7):648–656. doi: 10.1007/BF02239226. [DOI] [PubMed] [Google Scholar]
- Bradley J., Hawkins C. F., Rowe D. S., Stanworth D. R. Macroglobulinaemia and steatorrhoea. Gut. 1968 Oct;9(5):564–568. doi: 10.1136/gut.9.5.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CABRERA A., DELAPAVA S., PICKREN J. W. INTESTINAL LOCALIZATION OF WALDENSTROM'S DISEASE. Arch Intern Med. 1964 Sep;114:399–407. doi: 10.1001/archinte.1964.03860090133014. [DOI] [PubMed] [Google Scholar]
- Immunodeficiency disease and malignancy. Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease. Ann Intern Med. 1972 Oct;77(4):605–628. [PubMed] [Google Scholar]
- Khilnani M. T., Keller R. J., Cuttner J. Macroglobulinemia and steatorrhea: roentgen and pathologic findings in the intestinal tract. Radiol Clin North Am. 1969 Apr;7(1):43–55. [PubMed] [Google Scholar]
- Pruzanski W., Warren R. E., Goldie J. H., Katz A. Malabsorption syndrome with infiltration of the intestinal wall by extracellular monoclonal macroglobulin. Am J Med. 1973 Jun;54(6):811–818. doi: 10.1016/0002-9343(73)90070-3. [DOI] [PubMed] [Google Scholar]
- Sternberger L. A., Hardy P. H., Jr, Cuculis J. J., Meyer H. G. The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem. 1970 May;18(5):315–333. doi: 10.1177/18.5.315. [DOI] [PubMed] [Google Scholar]
- Tubbs R. R., McLaughlin J. P., Winkelman E. I., Deodhar S. D., Hewlett J. S. Macroglobulinemia and malabsorption. Cleve Clin Q. 1977 Winter;44(4):189–197. doi: 10.3949/ccjm.44.4.189. [DOI] [PubMed] [Google Scholar]