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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1983 Jan;36(1):51–56. doi: 10.1136/jcp.36.1.51

Prognostic value of tumour thickness in cutaneous malignant melanoma

Iona Jeffrey *, Patrick Royston *, Christopher Sowter *, Gerard Slavin *, Ashley Price *, Ariela Pomerance *, Saleem Goolamali *, Dominic Pinto *
PMCID: PMC498104  PMID: 6822677

Abstract

The relation between survival and histological features in 91 patients with malignant melanoma was studied and the results were analysed by Clayton's method for interpretation of censored survival data. There was a significant correlation between tumour thickness and survival. The risk of dying from malignant melanoma after 10 years of follow up was less than 15% if the primary tumour was less than 1·5 mm thick but more than 80% if the lesion was thicker than 8 mm.

The type of melanoma, level of invasion, mitotic rate, and presence of ulceration also correlated with survival, but these variables are related to tumour thickness.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Breslow A., Macht S. D. Evaluation of prognosis in Stage I cutaneous melanoma. Plast Reconstr Surg. 1978 Mar;61(3):342–346. doi: 10.1097/00006534-197803000-00006. [DOI] [PubMed] [Google Scholar]
  2. Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg. 1970 Nov;172(5):902–908. doi: 10.1097/00000658-197011000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Breslow A. Tumor thickness, level of invasion and node dissection in stage I cutaneous melanoma. Ann Surg. 1975 Nov;182(5):572–575. doi: 10.1097/00000658-197511000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clark W. H., Jr, From L., Bernardino E. A., Mihm M. C. The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res. 1969 Mar;29(3):705–727. [PubMed] [Google Scholar]
  5. Cochran A. J. Malignant melanoma. A REVIEW OF ') YEARS' experience in Glasgow, Scotland. Cancer. 1969 May;23(5):1190–1199. doi: 10.1002/1097-0142(196905)23:5<1190::aid-cncr2820230527>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  6. Eldh J., Boeryd B., Peterson L. E. Prognostic factors in cutaneous malignant melanoma in stage I. A clinical, morphological and multivariate analysis. Scand J Plast Reconstr Surg. 1978;12(3):243–255. doi: 10.3109/02844317809013000. [DOI] [PubMed] [Google Scholar]
  7. Gromet M. A., Epstein W. L., Blois M. S. The regressing thin malignant melanoma: a distinctive lesion with metastatic potential. Cancer. 1978 Nov;42(5):2282–2292. doi: 10.1002/1097-0142(197811)42:5<2282::aid-cncr2820420528>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  8. Hansen M. G., McCarten A. B. Tumor thickness and lymphocytic infiltration in malignant melanoma of the head and neck. Am J Surg. 1974 Oct;128(4):557–561. doi: 10.1016/0002-9610(74)90275-x. [DOI] [PubMed] [Google Scholar]
  9. Huvos A. G., Miké V., Donnellan M. J., Seemayer T., Strong E. W. Prognostic factors in cutaneous melanoma of the head and neck. Am J Pathol. 1973 Apr;71(1):33–48. [PMC free article] [PubMed] [Google Scholar]
  10. LANE N., LATTES R., MALM J. Clinicopathological correlations in a series of 117 malignant melanomas of the skin of adults. Cancer. 1958 Sep-Oct;11(5):1025–1043. doi: 10.1002/1097-0142(195809/10)11:5<1025::aid-cncr2820110525>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  11. Larsen T. E., Grude T. H. A retrospective histological study of 669 cases of primary cutaneous malignant melanoma in clinical stage I. I. Histological classification, sex and age of the patients, localization of tumour and prognosis. Acta Pathol Microbiol Scand A. 1978 Sep;86A(5):437–450. doi: 10.1111/j.1699-0463.1978.tb02068.x. [DOI] [PubMed] [Google Scholar]
  12. McGovern V. J., Mihm M. C., Jr, Bailly C., Booth J. C., Clark W. H., Jr, Cochran A. J., Hardy E. G., Hicks J. D., Levene A., Lewis M. G. The classification of malignant melanoma and its histologic reporting. Cancer. 1973 Dec;32(6):1446–1457. doi: 10.1002/1097-0142(197312)32:6<1446::aid-cncr2820320623>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  13. McGovern V. J., Shaw H. M., Milton G. W., Farago G. A. Prognostic significance of the histological features of malignant melanoma. Histopathology. 1979 Sep;3(5):385–393. doi: 10.1111/j.1365-2559.1979.tb03020.x. [DOI] [PubMed] [Google Scholar]
  14. McGovern V. J. Spontaneous regression of melanoma. Pathology. 1975 Apr;7(2):91–99. doi: 10.3109/00313027509092702. [DOI] [PubMed] [Google Scholar]
  15. McGovern V. J. The classification of melanoma and its relationship with prognosis. Pathology. 1970 Apr;2(2):85–98. doi: 10.3109/00313027009077330. [DOI] [PubMed] [Google Scholar]
  16. Schmoeckel C., Braun-Falco O. Prognostic index in malignant melanoma. Arch Dermatol. 1978 Jun;114(6):871–873. [PubMed] [Google Scholar]
  17. Wanebo H. J., Fortner J. G., Woodruff J., MacLean B., Binkowski E. Selection of the optimum surgical treatment of stage I melanoma by depth of microinvasion: Use of the combined microstage technique (Clark-Breslow). Ann Surg. 1975 Sep;182(3):302–315. doi: 10.1097/00000658-197509000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]

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