TABLE 1.

Species susceptibility to CWD infection following experimental exposure via the intracerebral (IC) or oral (PO) routes of exposure.

Species	Amino acid - position 170*	CWD – IC†	CWD – PO	References
Elk	N	ND	+++	54, 55
Fallow deer	N	+++	ND	56
Mule deer	N	ND	+++	57
White-tailed deer	N	+++	+++	7, 58
Reindeer	N	ND	++	59
Reeves' muntjac deer	N	ND	+++	60
Red deer	N	ND	+++	61
Shira's moose	N	ND	+++	62
Squirrel monkey	S	+++	+++	22-24
Macaque	S	0	0	23,24
Tg(humanPrP) (129V)	S	0	ND	38,39
Tg(humanPrP) (129M)	S	0	ND	17,36,38,39
Tg(humanPrP) (129MV)	S	0	ND	39
Sheep	S	+‡	ND	27
Tg(ovine PrP)	S	0	ND	36
Cattle	S	++	0	26
Tg(bovine PrP)	S	0	ND	36
Raccoon	S	0	ND	34
Ferret	S	+++	0	31,32
Mink	S	++	0	35
Cat	S	++	0	63
Chinese hamster	N	++	ND	33
Armenian hamster	N	+	ND	33
Syrian golden hamster	N	+	ND	33
Djungarian hamster	N	0	ND	33
Siberian hamster	N	+	ND	33
Tg(hamsterPrP)	N	++	ND	33
Prairie vole	N	+++	ND	30
Meadow vole	N	+++	ND	29
Red-backed vole	S/N	+++	ND	29
Bank vole	N	+++	ND	19
Deer mouse	N	++	ND	29
White-footed mouse	N	++	ND	29
C57/BL6 mouse	S	0	ND	33
Tg(mousePrP)-overexpressing PrP	S	+, +++	ND	36,64

^*Human numbering.

^†+++: 75–100%, ++: 25–74%, +: 0–24% to terminal prion disease.

^‡ARQ/VRQ only.