FIGURE 1.

Treatment with heterologous recombinant HaPrP delayed the onset of symptoms and prolonged survival. Kaplan-Meier plots showing the time at which mock-treated (orange, n = 5), low-dose-treated (blue, n = 5), high-dose-treated mice (purple, n = 6) and uninfected (red, n = 10) developed (A) detectable symptoms associated with scrapie infection, including ataxic gait, weight loss, and kyphosis, and (B) time of survival. We tested for differences between groups using a modified version of the Gehan-Wilcoxon test and found a statistically significant difference between the mock infected group and the high dose group (p = 0.0348). The low-dose group was not significantly different than the mock-treated control group. The uninfected control mice showed significantly longer survival times than the 3 groups of infected mice; uninfected versus mock (p = 0.008), uninfected vs. low dose (p = 0.006) and uninfected versus high dose (p = 0.0201).This figure is reprinted from our original article, Skinner et al., 2015, published in PloS ONE.