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. 1983 Feb;36(2):184–191. doi: 10.1136/jcp.36.2.184

Comparison of haematological indices between women of four ethnic groups and the effect of oral contraceptives.

I F Godsland, M Seed, R Simpson, G Broom, V Wynn
PMCID: PMC498147  PMID: 6826774

Abstract

Six-hundred-and-eighty-two women volunteers from four ethnic groups--Black, Indian, Oriental and White took part in a study to assess differences in haematological indices between the groups. This study was part of a broad investigation into the metabolic effects of oral contraceptives. The effect of the oral contraceptive (OC) on haematological indices was analysed but not found to be significant. The haemoglobin concentrations were lower than normal laboratory reference values for White subjects in 12.5% of Indian, 16.5% of Black and 4.3% of Oriental control groups respectively. All the White control group were within the normal range. These findings were considered in relation to age, weight, pregnancies, smoking, alcohol consumption, nutritional status, and disorders of haemoglobin synthesis. A deficient iron intake accounted for the high incidence of low haemoglobin in the Indian group in whom low transferrin saturation and serum ferritin were observed. With the possible exception of inherited disorders of haemoglobin synthesis, none of the factors we considered could account for the low haemoglobins found in the Black group. Separate reference values for haematological indices in different ethnic populations are considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burton J. L. Effect of oral contraceptives on haemoglobin, packed-cell volume, serum-iron, and total iron-binding capacity in healthy women. Lancet. 1967 May 6;1(7497):978–980. doi: 10.1016/s0140-6736(67)92359-8. [DOI] [PubMed] [Google Scholar]
  2. Callard G. V., Litofsky F. S., DeMerre L. J. Menstruation in women with normal or artificially controlled cycles. Fertil Steril. 1966 Sep-Oct;17(5):684–688. doi: 10.1016/s0015-0282(16)36070-8. [DOI] [PubMed] [Google Scholar]
  3. Chalmers D. M., Levi A. J., Chanarin I., North W. R., Meade T. W. Mean cell volume in a working population: the effects of age, smoking, alcohol and oral contraception. Br J Haematol. 1979 Dec;43(4):631–636. doi: 10.1111/j.1365-2141.1979.tb03796.x. [DOI] [PubMed] [Google Scholar]
  4. Chouhan D. M., Sharma R. S., Parekh J. G. Alpha-thalassaemia in India. J Indian Med Assoc. 1970 Apr 16;54(8):364–367. [PubMed] [Google Scholar]
  5. Dallman P. R., Barr G. D., Allen C. M., Shinefield H. R. Hemoglobin concentration in white, black, and Oriental children: is there a need for separate criteria in screening for anemia? Am J Clin Nutr. 1978 Mar;31(3):377–380. doi: 10.1093/ajcn/31.3.377. [DOI] [PubMed] [Google Scholar]
  6. Dodsworth H., Dean A., Broom G. Effects of smoking and the pill on the blood count. Br J Haematol. 1981 Nov;49(3):484–488. doi: 10.1111/j.1365-2141.1981.tb07253.x. [DOI] [PubMed] [Google Scholar]
  7. Dozy A. M., Kan Y. W., Embury S. H., Mentzer W. C., Wang W. C., Lubin B., Davis J. R., Jr, Koenig H. M. alpha-Globin gene organisation in blacks precludes the severe form of alpha-thalassaemia. Nature. 1979 Aug 16;280(5723):605–607. doi: 10.1038/280605a0. [DOI] [PubMed] [Google Scholar]
  8. Elwood P. C., Burr M. L., Hole D., Harrison A., Morris T. K., Wilson C. I., Richardson R. W., Shinton N. K. Nutritional state of elderly Asian and English subjects in Coventry. Lancet. 1972 Jun 3;1(7762):1224–1227. doi: 10.1016/s0140-6736(72)90938-5. [DOI] [PubMed] [Google Scholar]
  9. FAWCETT J. K., WYNN V. Effects of posture on plasma volume and some blood constituents. J Clin Pathol. 1960 Jul;13:304–310. doi: 10.1136/jcp.13.4.304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Garn S. M., Ryan A. S., Abraham S., Owen G. Suggested sex and age appropriate values for "low" and "deficient" hemoglobin levels. Am J Clin Nutr. 1981 Sep;34(9):1648–1651. doi: 10.1093/ajcn/34.9.1648. [DOI] [PubMed] [Google Scholar]
  11. Garn S. M., Ryan A. S., Owen G. M., Abraham S. Income matched black-white hemoglobin differences after correction for low transferrin saturations. Am J Clin Nutr. 1981 Sep;34(9):1645–1647. doi: 10.1093/ajcn/34.9.1645. [DOI] [PubMed] [Google Scholar]
  12. Garn S. M., Smith N. J., Clark D. C. Lifelong differences in hemoglobin levels between Blacks and Whites. J Natl Med Assoc. 1975 Mar;67(2):91–96. [PMC free article] [PubMed] [Google Scholar]
  13. Koh E. T., Chi M. S., Lowenstein F. W. Comparison of selected blood components by race, sex, and age. Am J Clin Nutr. 1980 Aug;33(8):1828–1835. doi: 10.1093/ajcn/33.8.1828. [DOI] [PubMed] [Google Scholar]
  14. Krishna Das K. V. Nutritional anaemias in India. J Assoc Physicians India. 1980 Dec;28(12):521–533. [PubMed] [Google Scholar]
  15. Lipschitz D. A., Cook J. D., Finch C. A. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med. 1974 May 30;290(22):1213–1216. doi: 10.1056/NEJM197405302902201. [DOI] [PubMed] [Google Scholar]
  16. Paton A. Oral contraceptives and folate deficiency. Lancet. 1969 Feb 22;1(7591):418–418. doi: 10.1016/s0140-6736(69)91386-5. [DOI] [PubMed] [Google Scholar]
  17. Pierce H. I., Kurachi S., Sofroniadou K., Stamatoyannopoulos G. Frequencies of thalassemia in American blacks. Blood. 1977 Jun;49(6):981–986. [PubMed] [Google Scholar]
  18. Prema K. Haemoglobin levels in contraceptive users. Indian J Med Res. 1979 May;69:756–760. [PubMed] [Google Scholar]
  19. Roberts P. D., James H., Petrie A., Morgan J. O., Hoffbrand A. V. Vitamin B 12 status in pregnancy among immigrants to Britain. Br Med J. 1973 Jul 14;3(5871):67–72. doi: 10.1136/bmj.3.5871.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Walford D. M., Deacon R. Alpha-thalassaemia trait in various racial groups in the United Kingdom: characterization of a variant of alpha-thalassaemia in Indians. Br J Haematol. 1976 Oct;34(2):193–206. doi: 10.1111/j.1365-2141.1976.tb00190.x. [DOI] [PubMed] [Google Scholar]
  21. Weippl G., Pantlitschko M., Bauer P., Lund S. Serumeisen-Normalwerte und statistische Verteilung der Einzelwerte bei Mann und Frau. Blut. 1973 Oct;27(4):261–269. doi: 10.1007/BF01637438. [DOI] [PubMed] [Google Scholar]
  22. Williams D. M. Racial differences of hemoglobin concentration: measurements of iron, copper, and zinc. Am J Clin Nutr. 1981 Sep;34(9):1694–1700. doi: 10.1093/ajcn/34.9.1694. [DOI] [PubMed] [Google Scholar]

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