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. 1983 Feb;36(2):203–207. doi: 10.1136/jcp.36.2.203

Early time course of the acute phase protein response in man.

C M Colley, A Fleck, A W Goode, B R Muller, M A Myers
PMCID: PMC498153  PMID: 6826776

Abstract

The rate at which the acute phase protein response occurred after both major and minor surgery was explored. Increases in the plasma concentration of C-reactive protein (CRP), alpha-1-acid glycoprotein (alpha 1 AG) and fibrinogen were not detected until 6-8 h after the initial incision. The peak concentration of CRP occurred at 48 h and that of fibrinogen at 96 h; alpha 1 AG concentrations rose rapidly until 48 h followed by little change until about 120 h. Although there was widespread variation in the concentrations of individual proteins in patients, severity of injury did not seem to have a significant effect on the time course of the change. Plasma cortisol concentration and the total white blood cell count (WBC) reached their peaks before the acute phase proteins, cortisol at 6 h and WBC at 12 h.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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