Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1983 Mar;36(3):280–288. doi: 10.1136/jcp.36.3.280

Nature of the inflammatory cell infiltrate in duodenitis.

M Hasan, F Hay, W Sircus, A Ferguson
PMCID: PMC498198  PMID: 6826779

Abstract

Counts of lamina propria and intraepithelial cells, lymphoid and polymorphonuclear, have been performed on semithin sections of endoscopic biopsies from the duodenum of patients with ulcer-associated duodenitis, with non-specific duodenitis, and from controls. In both types of duodenitis there were significant increases in lamina propria counts of plasma cells, lymphocytes and eosinophils, and in intraepithelial lymphocyte counts, when compared with controls. In control specimens, neutrophil polymorphs were very infrequent but a substantial neutrophil polymorph infiltration of the epithelium and lamina propria was present in both types of duodenitis. In biopsies from areas of duodenitis scanning electron microscopy showed the presence of cells, which are probably neutrophil polymorphs, on the luminal surface of the mucosa. Abnormalities in cell counts were present only in biopsies taken from visually inflamed areas of the duodenal bulb. These values returned to normal after healing of duodenitis with cimetidine. This study highlights the complex nature of the mucosal cellular infiltrate in in duodenitis, particularly the striking increase in polymorphonuclear leucocytes. Histopathological features of ulcer-associated and non-specific duodenitis are identical.

Full text

PDF
280

Images in this article

285Image
on p.285
285Image
on p.285
286Image
on p.286

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cheli R., Giacosa A. Inflammatory cell count and identification in chronic non specific duodenitis. Endoscopy. 1977 May;9(2):91–95. doi: 10.1055/s-0028-1098496. [DOI] [PubMed] [Google Scholar]
  2. Cotton P. B., Price A. B., Tighe J. R., Beales J. S. Preliminary evaluation of "duodenitis" by endoscopy and biopsy. Br Med J. 1973 Aug 25;3(5877):430–433. doi: 10.1136/bmj.3.5877.430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ferguson R., Allan R. N., Cooke W. T. A study of the cellular infiltrate of the proximal jejunal mucosa in ulcerative colitis and Crohn's disease. Gut. 1975 Mar;16(3):205–208. doi: 10.1136/gut.16.3.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ferguson R., Asquith P., Cooke W. T. The jejunal cellular infiltrate in coeliac disease complicated by lymphoma. Gut. 1974 Jun;15(6):458–461. doi: 10.1136/gut.15.6.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gelzayd E. A., Biederman M. A., Gelfand D. W. Changing concepts of duodenitis. Am J Gastroenterol. 1975 Sep;64(3):213–216. [PubMed] [Google Scholar]
  6. Greenlaw R., Sheahan D. G., DeLuca V., Miller D., Myerson D., Myerson P. Gastroduodenitis. A broader concept of peptic ulcer disease. Dig Dis Sci. 1980 Sep;25(9):660–672. doi: 10.1007/BF01308325. [DOI] [PubMed] [Google Scholar]
  7. Gregg J. A., Garabedian M. Duodenitis. Am J Gastroenterol. 1974 Mar;61(3):177–184. [PubMed] [Google Scholar]
  8. Hasan M., Ferguson A. Measurements of intestinal villi non-specific and ulcer-associated duodenitis-correlation between area of microdissected villus and villus epithelial cell count. J Clin Pathol. 1981 Oct;34(10):1181–1186. doi: 10.1136/jcp.34.10.1181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hasan M., Sircus W., Ferguson A. Duodenal mucosal architecture in non-specific and ulcer-associated duodenitis. Gut. 1981 Aug;22(8):637–641. doi: 10.1136/gut.22.8.637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Holmes G. K., Asquith P., Stokes P. L., Cooke W. T. Cellular infiltrate of jejunal biopsies in adult coeliac disease in relation to gluten withdrawal. Gut. 1974 Apr;15(4):278–283. [PMC free article] [PubMed] [Google Scholar]
  11. Joffe S. N., Lee F. D., Blumgart L. H. Duodenitis. Clin Gastroenterol. 1978 Sep;7(3):635–650. [PubMed] [Google Scholar]
  12. Korn E. R., Foroozan P. Endoscopic biopsies of normal duodenal mucosa. Gastrointest Endosc. 1974 Nov;21(2):51–54. doi: 10.1016/s0016-5107(74)73790-7. [DOI] [PubMed] [Google Scholar]
  13. Montgomery R. D., Shearer A. C. The cell population of the upper jejunal mucosa in tropical sprue and postinfective malabsorption. Gut. 1974 May;15(5):387–391. doi: 10.1136/gut.15.5.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Roca M., Truelove S. C., Whitehead R. Proceedings: The histological state of the gastric and duodenal mucosa in healthy volunteers. Gut. 1975 May;16(5):404–404. [PubMed] [Google Scholar]
  15. Strobel S., Hasan M., Ferguson A. Staining properties of human intestinal mucosal mast cells after glutaraldehyde fixation. J Clin Pathol. 1982 Aug;35(8):897–899. doi: 10.1136/jcp.35.8.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Thompson H., Holme G. Proceedings: The diagnosis of duodenitis. Gut. 1974 Oct;15(10):842–843. [PubMed] [Google Scholar]
  17. Whitehead R., Roca M., Meikle D. D., Skinner J., Truelove S. C. The histological classification of duodenitis in fibreoptic biopsy specimens. Digestion. 1975;13(3):129–136. doi: 10.1159/000197701. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES