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. 1983 Mar;36(3):312–315. doi: 10.1136/jcp.36.3.312

Antibody synthesis within the central nervous system: comparisons of CSF IgG indices and electrophoresis

EJ Thompson *, PG Riches †, J Kohn ‡
PMCID: PMC498203  PMID: 6826780

Abstract

Various laboratories have reported differing success rates in their ability to detect intrathecal synthesis of antibody when comparing the index of [Formula: see text] with electrophoretic analysis. We selected 44 patients in the borderline area of minimal and/or equivocal abnormality by IgG index. Electrophoretic analysis (on polyacrylamide gels for oligoclonal gamma globulin pattern) of parallel specimens was performed at the same time. The number of samples giving a normal index but showing oligoclonal bands varied between 34% and 43% depending on the cut-off point. The views about normal barrier functions underlying such indices are discussed with particular reference to the pathophysiology of the blood-CSF barrier.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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