Figure 1.

D-JNKI inhibits LPS-induced JNK activation in myometrium and neonatal brain. Timed pregnant CD-1 mice were injected on day 16 with Salmonella abortus LPS (1.0 μg) alone, LPS together with (1, 2 or 5 μg) of D-JNKI or with D-JNKI (5 μg) alone. Tissue samples from myometrium and fetal brain were isolated at 1 h post-treated and examined for JNK activity using an in vitro kinase assay. Maximal inhibition of LPS-induced JNK activation was achieved with 5 μg D-JNKI.