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. 1983 May;36(5):577–580. doi: 10.1136/jcp.36.5.577

Incidence of infection with hepatitis B virus in 56 patients with haemophilia A 1971-1979.

M L Stirling, J A Murray, P Mackay, S H Black, J F Peutherer, C A Ludlam
PMCID: PMC498290  PMID: 6404950

Abstract

During each of the four-year periods 1971-1975 and 1975-1979, the annual incidence of hepatitis B infection has been assessed in 56 patients with haemophilia A by measuring plasma HBsAg, anti-HBs and anti-HBc levels. Infection rates of 7% and 9.5% per annum respectively were observed for each four-year period despite the screening of individual blood donations for HBsAg by techniques up to the sensitivity of reversed passive haemagglutination. The highest incidence of seroconversion was amongst severe haemophiliacs many of whom had received treatment predominantly with cryoprecipitate. Of the 16 patients in whom serological evidence of hepatitis B infection was obtained only one had an accompanying clinical episode of hepatitis. We conclude that haemophiliacs are still at high risk of infection by hepatitis B virus despite the screening of individual blood donors for HBsAg.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bamber M., Murray A., Arborgh B. A., Scheuer P. J., Kernoff P. B., Thomas H. C., Sherlock S. Short incubation non-A, non-B hepatitis transmitted by factor VIII concentrates in patients with congenital coagulation disorders. Gut. 1981 Oct;22(10):854–859. doi: 10.1136/gut.22.10.854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Burrell C. J., Black S. H., Ramsay D. M. Antibody to hepatitis B surface antigen in haemophiliacs on long-term therapy with Scottish factor VIII. J Clin Pathol. 1978 Apr;31(4):309–312. doi: 10.1136/jcp.31.4.309. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Craske J., Spooner R. J., Vandervelde E. M. Evidence for existence of at least two types of factor-VIII-associated non-B transfusion hepatitis. Lancet. 1978 Nov 11;2(8098):1051–1052. doi: 10.1016/s0140-6736(78)92374-7. [DOI] [PubMed] [Google Scholar]
  4. Gocke D. J., Greenberg H. B., Kavey N. B. Hepatitis antigen. Detection of infectious blood donors. Lancet. 1969 Aug 2;2(7614):248–249. doi: 10.1016/s0140-6736(69)90011-7. [DOI] [PubMed] [Google Scholar]
  5. Hopkins R., Das P. C. A tanned cell haemagglutination test for the detection of hepatitis-associated-antigen (Au-Ag) and antibody (anti-Au). Br J Haematol. 1973 Nov;25(5):619–629. doi: 10.1111/j.1365-2141.1973.tb01775.x. [DOI] [PubMed] [Google Scholar]
  6. Hopkins R., Ross S., Barr A., McClelland D. B. Selection of plasma for hepatitis B immune globulin using a low cost radioimmunoassay. Vox Sang. 1981 Jan;40(1):6–11. doi: 10.1111/j.1423-0410.1981.tb00662.x. [DOI] [PubMed] [Google Scholar]
  7. Norkrans G., Widell A., Teger-Nilsson A. C., Kjellman H., Frösner G., Iwarson S. Acute hepatitis non-A, non-B following administration of factor VIII concentrates. Vox Sang. 1981 Sep;41(3):129–133. doi: 10.1111/j.1423-0410.1981.tb01025.x. [DOI] [PubMed] [Google Scholar]
  8. Peutherer J. F., MacKay P., Ross R., Stahl S., Murray K. Use of the hepatitis B core antigen produced in Escherichia coli in an assay for anti-HBc. Med Lab Sci. 1981 Oct;38(4):355–358. [PubMed] [Google Scholar]
  9. Prince A. M., Stephan W., Brotman B., van den Ende M. C. Evaluation of the effect of betapropiolactone/ultraviolet irradiation (BPL/UV) treatment of source plasma on hepatitis transmission by factor IX complex in chimpanzees. Thromb Haemost. 1980 Dec 19;44(3):138–142. [PubMed] [Google Scholar]
  10. Rickard K. A., Batey R. G., Dority P., Johnson S., Campbell J., Hodgson J. Hepatitis and haemophilia therapy in Australia. Lancet. 1982 Jul 17;2(8290):146–148. doi: 10.1016/s0140-6736(82)91105-9. [DOI] [PubMed] [Google Scholar]
  11. Stirling M. L., Beckett G. J., Percy-Robb I. W. Liver function in Edinburgh haemophiliacs: a five-year follow-up. J Clin Pathol. 1981 Jan;34(1):17–20. doi: 10.1136/jcp.34.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Szmuness W., Stevens C. E., Harley E. J., Zang E. A., Oleszko W. R., William D. C., Sadovsky R., Morrison J. M., Kellner A. Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States. N Engl J Med. 1980 Oct 9;303(15):833–841. doi: 10.1056/NEJM198010093031501. [DOI] [PubMed] [Google Scholar]
  13. Tsiquaye K. N., Zuckerman A. J. New human hepatitis virus. Lancet. 1979 May 26;1(8126):1135–1136. doi: 10.1016/s0140-6736(79)91808-7. [DOI] [PubMed] [Google Scholar]

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