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. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: Atherosclerosis. 2016 Jun 7;251:422–429. doi: 10.1016/j.atherosclerosis.2016.05.049

Table 3. Evaluation of potential race/ethnicity effect heterogeneity of ABO alleles on protein measurements.

Results based on race/ethnicity-pooled association analysis and random effects meta-analysis.

vWF

	Pooled Analysis				Meta-Analysis

Allele	Beta (SE)	p	Interaction Test p		Beta (SE)	p	Heterogeneity
Allele	Beta (SE)	p	Allele	Omnibus	Beta (SE)	p	Q	p	I²
A1	0.25 (0.02)	<1E-08	0.99	0.83	0.25 (0.02)	<1E-08	0.40	0.94	2.0%
A2	0.08 (0.04)	0.020	0.27	-	0.10 (0.06)	0.051	4.23	0.12	52.3%
B	0.33 (0.03)	<1E-08	0.64	-	0.32 (0.03)	<1E-08	1.60	0.66	13.3%

sE-selectin

	Pooled Analysis				Meta-Analysis

Allele	Beta (SE)	p	Interaction Test p		Beta (SE)	p	Heterogeneity
Allele	Beta (SE)	p	Allele	Omnibus	Beta (SE)	p	Q	p	I²

A1	−0.47 (0.02)	<1E-08	0.20	0.0085	−0.45 (0.04)	<1E-08	5.80	0.12	51.0 %
A2	−0.06 (0.04)	0.13	7.5E-04	-	0.02 (0.12)	0.88	18.33	1.0E-04	88.0%
B	−0.04 (0.03)	0.13	0.73	-	−0.03 (0.03)	0.33	0.35	0.95	0.9%

sP-selectin

	Pooled Analysis				Meta-Analysis

Allele	Beta (SE)	p	Interaction Test p		Beta (SE)	p	Heterogeneity
Allele	Beta (SE)	p	Allele	Omnibus	Beta (SE)	p	Q	p	I²

A1	−0.17 (0.01)	<1E-08	0.16	0.012	−0.17 (0.02)	<1E-08	6.53	0.088	62.4%
A2	−0.01 (0.02)	0.67	0.58	-	−0.00 (0.02)	0.87	0.81	0.67	7.1%
B	0.03 (0.01)	0.025	0.011	-	0.05 (0.03)	0.19	11.22	7.0E-04	82.5%

sICAM-1

	Pooled Analysis				Meta-Analysis

Allele	Beta (SE)	p	Interaction Test p		Beta (SE)	p	Heterogeneity
Allele	Beta (SE)	p	Allele	Omnibus	Beta (SE)	p	Q	p	I²

A1	−0.05 (0.01)	2.4E-05	0.40	0.41	−0.05 (0.01)	2.8E-04	2.61	0.46	27.0%
A2	−0.02 (0.02)	0.29	0.21	-	−0.02 (0.04)	0.48	3.20	0.20	51.6%
B	0.01 (0.01)	0.49	0.53	-	0.01 (0.02)	0.63	2.68	0.44	32.7%