Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1983 Jun;36(6):693–696. doi: 10.1136/jcp.36.6.693

Increased mean platelet volume in septicaemia.

J Van der Lelie, A K Von dem Borne
PMCID: PMC498352  PMID: 6343437

Abstract

An increased mean platelet volume (MPV), measured by the Coulter counter model S plus, was found in 13 of 25 patients with proven septicaemia but in none of 25 patients with localised bacterial infection and negative blood cultures. The increase in MPV was found both in patients with normal and low platelet counts and was not related to a particular micro-organism. Patients who responded favourably to antibiotic treatment all had normal MPVs after one week of treatment. However, 9 of 11 patients with a prolonged course of their infection due to endocarditis or abdominal abscesses had raised MPVs after seven days of treatment, and four patients who died of infection in the first week all had increased MPVs on the day of their death. An increased MPV in a patient with bacterial infection possibly indicates that the infection has become invasive--that is, that septicaemia has occurred. A persistent rise or further increase indicates that treatment is inadequate.

Full text

PDF
693

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bessman J. D. Evaluation of automated whole-blood platelet counts and particle sizing. Am J Clin Pathol. 1980 Aug;74(2):157–162. doi: 10.1093/ajcp/74.2.157. [DOI] [PubMed] [Google Scholar]
  2. Corrigan J. J., Jr, Ray W. L., May N. Changes in the blood coagulation system associated with septicemia. N Engl J Med. 1968 Oct 17;279(16):851–856. doi: 10.1056/NEJM196810172791603. [DOI] [PubMed] [Google Scholar]
  3. Corrigan J. J., Jr Thrombocytopenia: a laboratory sign of septicemia in infants and children. J Pediatr. 1974 Aug;85(2):219–221. doi: 10.1016/s0022-3476(74)80396-3. [DOI] [PubMed] [Google Scholar]
  4. Eldor A., Avitzour M., Or R., Hanna R., Penchas S. Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume. Br Med J (Clin Res Ed) 1982 Aug 7;285(6339):397–400. doi: 10.1136/bmj.285.6339.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Giles C. The platelet count and mean platelet volume. Br J Haematol. 1981 May;48(1):31–37. doi: 10.1111/j.1365-2141.1981.00031.x. [DOI] [PubMed] [Google Scholar]
  6. Godal H. C., Abildgaard U. Gelation of soluble fibrin in plasma by ethanol. Scand J Haematol. 1966;3(5):342–350. doi: 10.1111/j.1600-0609.1966.tb02378.x. [DOI] [PubMed] [Google Scholar]
  7. Hawiger J., Hawiger A., Steckley S., Timmons S., Cheng C. Membrane changes in human platelets induced by lipopolysaccharide endotoxin. Br J Haematol. 1977 Feb;35(2):285–299. doi: 10.1111/j.1365-2141.1977.tb00585.x. [DOI] [PubMed] [Google Scholar]
  8. Karpatkin S., Garg S. K., Siskind G. W. Autoimmune thrombocytopenic purpura and the compensated thrombocytolytic state. Am J Med. 1971 Jul;51(1):1–4. doi: 10.1016/0002-9343(71)90317-2. [DOI] [PubMed] [Google Scholar]
  9. Karpatkin S. Heterogeneity of human platelets. I. Metabolic and kinetic evidence suggestive of young and old platelets. J Clin Invest. 1969 Jun;48(6):1073–1082. doi: 10.1172/JCI106063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McCabe W. R. Serum complement levels in bacteremia due to gram-negative organisms. N Engl J Med. 1973 Jan 4;288(1):21–23. doi: 10.1056/NEJM197301042880105. [DOI] [PubMed] [Google Scholar]
  11. Meuer S., Ecker U., Hadding U., Bitter-Suermann D. Platelet-serotonin release by C3a and C5a: two independent pathways of activation. J Immunol. 1981 Apr;126(4):1506–1509. [PubMed] [Google Scholar]
  12. Nelson R. B., 3rd, Kehl D. Electronically determined platelet indices in thrombocytopenic patients. Cancer. 1981 Aug 15;48(4):954–956. doi: 10.1002/1097-0142(19810815)48:4<954::aid-cncr2820480417>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  13. Paulus J. M. Platelet size in man. Blood. 1975 Sep;46(3):321–336. [PubMed] [Google Scholar]
  14. Penington D. G., Lee N. L., Roxburgh A. E., McGready J. R. Platelet density and size: the interpretation of heterogeneity. Br J Haematol. 1976 Nov;34(3):365–376. doi: 10.1111/j.1365-2141.1976.tb03583.x. [DOI] [PubMed] [Google Scholar]
  15. Reimers H. J., Kinlough-Rathbone R. L., Cazenave J. P., Senyi A. F., Hirsh J., Packham M. A., Mustard J. F. In vitro and in vivo functions of thrombin-treated platelets. Thromb Haemost. 1976 Feb 29;35(1):151–166. [PubMed] [Google Scholar]
  16. Rowan R. M., Fraser C., Gray J. H., McDonald G. A. The Coulter Counter Model S Plus--the shape of things to come. Clin Lab Haematol. 1979;1(1):29–40. doi: 10.1111/j.1365-2257.1979.tb00587.x. [DOI] [PubMed] [Google Scholar]
  17. Zimmerman T. S., Spiegelberg H. L. Pneumococcus-induced serotonin release from human platelets. Identification of the participating plasma/serum factor as immunoglobulin. J Clin Invest. 1975 Oct;56(4):828–834. doi: 10.1172/JCI108161. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES