Abstract
A Mallory body (alcoholic hyaline) antigen (JMB2) which is also present in intermediate filaments of epithelial origin was demonstrated immunohistochemically in renal glomeruli of three out of eleven patients with alcoholic liver damage. In two of these patients, both of whom had alcoholic cirrhosis with Mallory bodies, it was associated with mesangial deposits of IgA and C3. JMB2 was not found in glomeruli of normal controls, nor in a series of cases of glomerulonephritis in non-alcoholic patients. It is concluded that JMB2 is present in immune complexes in renal glomeruli of patients with renal disease consequent on alcoholic liver disease.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berger J., Yaneva H., Nabarra B. Glomerular changes in patients with cirrhosis of the liver. Adv Nephrol Necker Hosp. 1977;7:3–14. [PubMed] [Google Scholar]
- Callard P., Feldmann G., Prandi D., Belair M. F., Mandet C., Weiss Y., Druet P., Benhamou J. P., Bariety J. Immune complex type glomerulonephritis in cirrhosis of the liver. Am J Pathol. 1975 Aug;80(2):329–340. [PMC free article] [PubMed] [Google Scholar]
- Edgington T. S., Glassock R. J., Dixon F. J. Autologous immune complex nephritis induced with renal tubular antigen. I. Identification and isolation of the pathogenetic antigen. J Exp Med. 1968 Mar 1;127(3):555–572. doi: 10.1084/jem.127.3.555. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gormly A. A., Smith P. S., Seymour A. E., Clarkson A. R., Woodroffe A. J. IgA glomerular deposits in experimental cirrhosis. Am J Pathol. 1981 Jul;104(1):50–54. [PMC free article] [PubMed] [Google Scholar]
- Kanagasundaram N., Kakumu S., Chen T., Leevy C. M. Alcoholic hyalin antigen (AHAg) and antibody (AHAb) in alcoholic hepatitis. Gastroenterology. 1977 Dec;73(6):1368–1373. [PubMed] [Google Scholar]
- Nakamoto Y., Iida H., Kobayashi K., Dohi K., Kida H., Hattori N., Takeuchi J. Hepatic glomerulonephritis. Characteristics of hepatic IgA glomerulonephritis as the major part. Virchows Arch A Pathol Anat Histol. 1981;392(1):45–54. doi: 10.1007/BF00430547. [DOI] [PubMed] [Google Scholar]
- Nochy D., Callard P., Bellon B., Bariety J., Druet P. Association of overt glomerulonephritis and liver disease: a study of 34 patients. Clin Nephrol. 1976 Oct;6(4):422–427. [PubMed] [Google Scholar]
- Penner E., Albini B., Milgrom F. Detection of circulating immune complexes in alcoholic liver disease. Clin Exp Immunol. 1978 Oct;34(1):28–31. [PMC free article] [PubMed] [Google Scholar]
- Sancho J., Egido J., Sánchez-Crespo M., Blasco R. Detection of monomeric and polymeric IgA containing immune complexes in serum and kidney from patients with alcoholic liver disease. Clin Exp Immunol. 1982 Feb;47(2):327–335. [PMC free article] [PubMed] [Google Scholar]
- Swerdlow M. A., Chowdhury L. N., Horn T. Patterns of IgA deposition in liver tissues in alcoholic liver disease. Am J Clin Pathol. 1982 Mar;77(3):259–266. doi: 10.1093/ajcp/77.3.259. [DOI] [PubMed] [Google Scholar]
- Williams D. G. New ideas in the pathogenesis of nephritis. J Clin Pathol. 1981 Nov;34(11):1223–1227. doi: 10.1136/jcp.34.11.1223. [DOI] [PMC free article] [PubMed] [Google Scholar]